Death begets failure in the heart

Roger S Y Foo, Kartik Mani, Richard N. Kitsis

Research output: Contribution to journalArticle

247 Citations (Scopus)

Abstract

Recently, low - but abnormal - rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalJournal of Clinical Investigation
Volume115
Issue number3
DOIs
StatePublished - Mar 2005

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Cardiac Myocytes
Rodentia
Cell Death
Heart Failure
Pharmacology
Apoptosis
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Death begets failure in the heart. / Foo, Roger S Y; Mani, Kartik; Kitsis, Richard N.

In: Journal of Clinical Investigation, Vol. 115, No. 3, 03.2005, p. 565-571.

Research output: Contribution to journalArticle

Foo, Roger S Y ; Mani, Kartik ; Kitsis, Richard N. / Death begets failure in the heart. In: Journal of Clinical Investigation. 2005 ; Vol. 115, No. 3. pp. 565-571.
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