De novo lipogenesis in health and disease

Fatima Ameer, Lisa Scandiuzzi, Shahida Hasnain, Hubert Kalbacher, Nousheen Zaidi

Research output: Contribution to journalReview article

158 Scopus citations

Abstract

Background De novo lipogenesis (DNL) is a complex and highly regulated metabolic pathway. In normal conditions DNL converts excess carbohydrate into fatty acids that are then esterified to storage triacylglycerols (TGs). These TGs could later provide energy via β-oxidation. In human body this pathway is primarily active in liver and adipose tissue. However, it is considered to be a minor contributor to the serum lipid homeostasis. Deregulations in the lipogenic pathway are associated with diverse pathological conditions. Scope of review The present review focuses on our current understanding of the lipogenic pathway with special reference to the causes and consequences of aberrant DNL. Major conclusions The deregulation of DNL in the major lipogenic tissues of the human body is often observed in various metabolic anomalies - including obesity, non-alcoholic fatty liver disease and metabolic syndrome. In addition to that de novo lipogenesis is reported to be exacerbated in cancer tissues, virus infected cells etc. These observations suggest that inhibitors of the DNL pathway might serve as therapeutically significant compounds. The effectiveness of these inhibitors in treatment of cancer and obesity has been suggested by previous works. General significance De novo lipogenesis - which is an intricate and highly regulated pathway - can lead to adverse metabolic consequences when deregulated. Therapeutic targeting of this pathway may open a new window of opportunity for combating various lipogenesis-driven pathological conditions - including obesity, cancer and certain viral infections.

Original languageEnglish (US)
Pages (from-to)895-902
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume63
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Cancer
  • De novo lipogenesis
  • Fatty Acid Synthase
  • Non-alcoholic fatty liver disease
  • Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'De novo lipogenesis in health and disease'. Together they form a unique fingerprint.

  • Cite this

    Ameer, F., Scandiuzzi, L., Hasnain, S., Kalbacher, H., & Zaidi, N. (2014). De novo lipogenesis in health and disease. Metabolism: Clinical and Experimental, 63(7), 895-902. https://doi.org/10.1016/j.metabol.2014.04.003