Day to day treatment variations of accelerated partial breast brachytherapy using a multi-lumen balloon

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8 Citations (Scopus)

Abstract

Purpose: To evaluate the variations of multi-lumen balloon (MLB)-based brachytherapy from simulation day to treatment day and their dosimetric impacts during accelerated partial breast irradiation (APBI). Material and methods: A total of 42 CT images scanned from seven patients were evaluated with regards to daily variation due to of: 1) internal uncertainty: size and shape of balloon, seroma volume; 2) geometrical uncertainty-random: length of each catheter was measured for each fraction (total 70); 3) geometrical uncertainty-systematic: virtual systematic errors were tested by offsetting dwell positions. The original plans (as group A) had a mean value of 96.8% on V95 of the PTV-Eval. Plans were rerun (as group B) such that the mean value of the V 95 was relaxed to 90.4%. By applying the reference plan to each daily CT image, variations of target coverage under different sources of error were evaluated. Results: Shape and size of the balloon had means of < 1 mm decreased in diameter and < 0.4 cm3 decreased in volume; the mean seroma volume increased by 0.2 cm3. This internal variation has a mean of < 1% difference for both V90 and V95. The geometrical uncertainty made a mean deviation of 2.7 mm per root of sum of square. It caused the degradations of V90 and V95 by mean values of 1.0% and 1.2%, respectively. A systematic error of 3 mm and 4 mm would degrade both of V90 and V95 by 4% and 6%, respectively. The degradations on target coverage of the plans in group A were statistically the same as those in group B. Conclusions: Overall, APBI treatments with MLB based brachytherapy are precise from day to day. However, minor variation due to daily treatment uncertainties can still degrade tumor bed coverage to an unacceptable coverage when V95 of the original plan is close to 90%.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalJournal of Contemporary Brachytherapy
Volume6
Issue number1
DOIs
StatePublished - 2014

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Brachytherapy
Uncertainty
Breast
Seroma
Therapeutics
Research Design
Catheters
Neoplasms

Keywords

  • APBI
  • Brachytherapy
  • Breast cancer
  • Contura
  • Multi-lumen balloon
  • Treatment uncertainty

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

@article{9cdef5cf4c2647babb956bdd4f8bc1f4,
title = "Day to day treatment variations of accelerated partial breast brachytherapy using a multi-lumen balloon",
abstract = "Purpose: To evaluate the variations of multi-lumen balloon (MLB)-based brachytherapy from simulation day to treatment day and their dosimetric impacts during accelerated partial breast irradiation (APBI). Material and methods: A total of 42 CT images scanned from seven patients were evaluated with regards to daily variation due to of: 1) internal uncertainty: size and shape of balloon, seroma volume; 2) geometrical uncertainty-random: length of each catheter was measured for each fraction (total 70); 3) geometrical uncertainty-systematic: virtual systematic errors were tested by offsetting dwell positions. The original plans (as group A) had a mean value of 96.8{\%} on V95 of the PTV-Eval. Plans were rerun (as group B) such that the mean value of the V 95 was relaxed to 90.4{\%}. By applying the reference plan to each daily CT image, variations of target coverage under different sources of error were evaluated. Results: Shape and size of the balloon had means of < 1 mm decreased in diameter and < 0.4 cm3 decreased in volume; the mean seroma volume increased by 0.2 cm3. This internal variation has a mean of < 1{\%} difference for both V90 and V95. The geometrical uncertainty made a mean deviation of 2.7 mm per root of sum of square. It caused the degradations of V90 and V95 by mean values of 1.0{\%} and 1.2{\%}, respectively. A systematic error of 3 mm and 4 mm would degrade both of V90 and V95 by 4{\%} and 6{\%}, respectively. The degradations on target coverage of the plans in group A were statistically the same as those in group B. Conclusions: Overall, APBI treatments with MLB based brachytherapy are precise from day to day. However, minor variation due to daily treatment uncertainties can still degrade tumor bed coverage to an unacceptable coverage when V95 of the original plan is close to 90{\%}.",
keywords = "APBI, Brachytherapy, Breast cancer, Contura, Multi-lumen balloon, Treatment uncertainty",
author = "Hsiang-Chi Kuo and Mehta, {Keyur J.} and Linda Hong and Ravindra Yaparpalvi and Montgomery, {Leslie L.} and Bodner, {William R.} and Tome, {Wolfgang A.} and Shalom Kalnicki",
year = "2014",
doi = "10.5114/jcb.2014.42025",
language = "English (US)",
volume = "6",
pages = "68--75",
journal = "Journal of Contemporary Brachytherapy",
issn = "1689-832X",
publisher = "Termedia Publishing House Ltd.",
number = "1",

}

TY - JOUR

T1 - Day to day treatment variations of accelerated partial breast brachytherapy using a multi-lumen balloon

AU - Kuo, Hsiang-Chi

AU - Mehta, Keyur J.

AU - Hong, Linda

AU - Yaparpalvi, Ravindra

AU - Montgomery, Leslie L.

AU - Bodner, William R.

AU - Tome, Wolfgang A.

AU - Kalnicki, Shalom

PY - 2014

Y1 - 2014

N2 - Purpose: To evaluate the variations of multi-lumen balloon (MLB)-based brachytherapy from simulation day to treatment day and their dosimetric impacts during accelerated partial breast irradiation (APBI). Material and methods: A total of 42 CT images scanned from seven patients were evaluated with regards to daily variation due to of: 1) internal uncertainty: size and shape of balloon, seroma volume; 2) geometrical uncertainty-random: length of each catheter was measured for each fraction (total 70); 3) geometrical uncertainty-systematic: virtual systematic errors were tested by offsetting dwell positions. The original plans (as group A) had a mean value of 96.8% on V95 of the PTV-Eval. Plans were rerun (as group B) such that the mean value of the V 95 was relaxed to 90.4%. By applying the reference plan to each daily CT image, variations of target coverage under different sources of error were evaluated. Results: Shape and size of the balloon had means of < 1 mm decreased in diameter and < 0.4 cm3 decreased in volume; the mean seroma volume increased by 0.2 cm3. This internal variation has a mean of < 1% difference for both V90 and V95. The geometrical uncertainty made a mean deviation of 2.7 mm per root of sum of square. It caused the degradations of V90 and V95 by mean values of 1.0% and 1.2%, respectively. A systematic error of 3 mm and 4 mm would degrade both of V90 and V95 by 4% and 6%, respectively. The degradations on target coverage of the plans in group A were statistically the same as those in group B. Conclusions: Overall, APBI treatments with MLB based brachytherapy are precise from day to day. However, minor variation due to daily treatment uncertainties can still degrade tumor bed coverage to an unacceptable coverage when V95 of the original plan is close to 90%.

AB - Purpose: To evaluate the variations of multi-lumen balloon (MLB)-based brachytherapy from simulation day to treatment day and their dosimetric impacts during accelerated partial breast irradiation (APBI). Material and methods: A total of 42 CT images scanned from seven patients were evaluated with regards to daily variation due to of: 1) internal uncertainty: size and shape of balloon, seroma volume; 2) geometrical uncertainty-random: length of each catheter was measured for each fraction (total 70); 3) geometrical uncertainty-systematic: virtual systematic errors were tested by offsetting dwell positions. The original plans (as group A) had a mean value of 96.8% on V95 of the PTV-Eval. Plans were rerun (as group B) such that the mean value of the V 95 was relaxed to 90.4%. By applying the reference plan to each daily CT image, variations of target coverage under different sources of error were evaluated. Results: Shape and size of the balloon had means of < 1 mm decreased in diameter and < 0.4 cm3 decreased in volume; the mean seroma volume increased by 0.2 cm3. This internal variation has a mean of < 1% difference for both V90 and V95. The geometrical uncertainty made a mean deviation of 2.7 mm per root of sum of square. It caused the degradations of V90 and V95 by mean values of 1.0% and 1.2%, respectively. A systematic error of 3 mm and 4 mm would degrade both of V90 and V95 by 4% and 6%, respectively. The degradations on target coverage of the plans in group A were statistically the same as those in group B. Conclusions: Overall, APBI treatments with MLB based brachytherapy are precise from day to day. However, minor variation due to daily treatment uncertainties can still degrade tumor bed coverage to an unacceptable coverage when V95 of the original plan is close to 90%.

KW - APBI

KW - Brachytherapy

KW - Breast cancer

KW - Contura

KW - Multi-lumen balloon

KW - Treatment uncertainty

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DO - 10.5114/jcb.2014.42025

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