DARPP-32

Regulator of the efficacy of dopaminergic neurotransmission

A. A. Fienberg, Noboru Hiroi, P. G. Mermelstein, W. J. Song, G. L. Snyder, A. Nishi, A. Cheramy, J. P. O'Callaghan, D. B. Miller, D. G. Cole, R. Corbett, C. N. Haile, D. C. Cooper, S. P. Onn, A. A. Grace, C. C. Ouimet, F. J. White, S. E. Hyman, D. J. Surmeier, J. A. Girault & 2 others E. J. Nestler, P. Greengard

Research output: Contribution to journalArticle

366 Citations (Scopus)

Abstract

Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

Original languageEnglish (US)
Pages (from-to)838-842
Number of pages5
JournalScience
Volume281
Issue number5378
DOIs
StatePublished - Aug 7 1998
Externally publishedYes

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Dopamine and cAMP-Regulated Phosphoprotein 32
Dopamine Agents
Phosphoprotein Phosphatases
Dopaminergic Neurons
Street Drugs
Prosencephalon
Synaptic Transmission
Antipsychotic Agents
Dopamine
Neurons
Genes

ASJC Scopus subject areas

  • General

Cite this

Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W. J., Snyder, G. L., Nishi, A., ... Greengard, P. (1998). DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. Science, 281(5378), 838-842. https://doi.org/10.1126/science.281.5378.838

DARPP-32 : Regulator of the efficacy of dopaminergic neurotransmission. / Fienberg, A. A.; Hiroi, Noboru; Mermelstein, P. G.; Song, W. J.; Snyder, G. L.; Nishi, A.; Cheramy, A.; O'Callaghan, J. P.; Miller, D. B.; Cole, D. G.; Corbett, R.; Haile, C. N.; Cooper, D. C.; Onn, S. P.; Grace, A. A.; Ouimet, C. C.; White, F. J.; Hyman, S. E.; Surmeier, D. J.; Girault, J. A.; Nestler, E. J.; Greengard, P.

In: Science, Vol. 281, No. 5378, 07.08.1998, p. 838-842.

Research output: Contribution to journalArticle

Fienberg, AA, Hiroi, N, Mermelstein, PG, Song, WJ, Snyder, GL, Nishi, A, Cheramy, A, O'Callaghan, JP, Miller, DB, Cole, DG, Corbett, R, Haile, CN, Cooper, DC, Onn, SP, Grace, AA, Ouimet, CC, White, FJ, Hyman, SE, Surmeier, DJ, Girault, JA, Nestler, EJ & Greengard, P 1998, 'DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission', Science, vol. 281, no. 5378, pp. 838-842. https://doi.org/10.1126/science.281.5378.838
Fienberg AA, Hiroi N, Mermelstein PG, Song WJ, Snyder GL, Nishi A et al. DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. Science. 1998 Aug 7;281(5378):838-842. https://doi.org/10.1126/science.281.5378.838
Fienberg, A. A. ; Hiroi, Noboru ; Mermelstein, P. G. ; Song, W. J. ; Snyder, G. L. ; Nishi, A. ; Cheramy, A. ; O'Callaghan, J. P. ; Miller, D. B. ; Cole, D. G. ; Corbett, R. ; Haile, C. N. ; Cooper, D. C. ; Onn, S. P. ; Grace, A. A. ; Ouimet, C. C. ; White, F. J. ; Hyman, S. E. ; Surmeier, D. J. ; Girault, J. A. ; Nestler, E. J. ; Greengard, P. / DARPP-32 : Regulator of the efficacy of dopaminergic neurotransmission. In: Science. 1998 ; Vol. 281, No. 5378. pp. 838-842.
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AU - Fienberg, A. A.

AU - Hiroi, Noboru

AU - Mermelstein, P. G.

AU - Song, W. J.

AU - Snyder, G. L.

AU - Nishi, A.

AU - Cheramy, A.

AU - O'Callaghan, J. P.

AU - Miller, D. B.

AU - Cole, D. G.

AU - Corbett, R.

AU - Haile, C. N.

AU - Cooper, D. C.

AU - Onn, S. P.

AU - Grace, A. A.

AU - Ouimet, C. C.

AU - White, F. J.

AU - Hyman, S. E.

AU - Surmeier, D. J.

AU - Girault, J. A.

AU - Nestler, E. J.

AU - Greengard, P.

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