DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission

A. A. Fienberg, N. Hiroi, P. G. Mermelstein, W. J. Song, G. L. Snyder, A. Nishi, A. Cheramy, J. P. O'Callaghan, D. B. Miller, D. G. Cole, R. Corbett, C. N. Haile, D. C. Cooper, S. P. Onn, A. A. Grace, C. C. Ouimet, F. J. White, S. E. Hyman, D. J. Surmeier, J. A. GiraultE. J. Nestler, P. Greengard

Research output: Contribution to journalArticle

369 Scopus citations

Abstract

Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

Original languageEnglish (US)
Pages (from-to)838-842
Number of pages5
JournalScience
Volume281
Issue number5378
DOIs
StatePublished - Aug 7 1998

ASJC Scopus subject areas

  • General

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    Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W. J., Snyder, G. L., Nishi, A., Cheramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., Corbett, R., Haile, C. N., Cooper, D. C., Onn, S. P., Grace, A. A., Ouimet, C. C., White, F. J., Hyman, S. E., Surmeier, D. J., ... Greengard, P. (1998). DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. Science, 281(5378), 838-842. https://doi.org/10.1126/science.281.5378.838