Dapagliflozin inhibits cell adhesion to collagen I and IV and increases ectodomain proteolytic cleavage of DDR1 by increasing ADAM10 activity

Physics & Astronomy

• glucose 63%
• collagens 62%
• diabetes mellitus 62%
• cleavage 56%
• adhesion 46%
• cancer 40%
• sodium 37%
• cells 29%
• chemotherapy 26%
• therapy 17%
• tyrosine 8%
• phosphorylation 8%
• kidneys 7%
• inhibitors 7%
• liver 6%
• lungs 6%
• detachment 6%
• enzymes 6%
• radiation therapy 6%
• proteins 4%
• interactions 4%
• products 3%
• sensitivity 3%

Medicine & Life Sciences

• 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol 85%
• Cell Adhesion 51%
• Collagen 41%
• Sodium-Glucose Transport Proteins 30%
• 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol 17%
• empagliflozin 14%
• Type 2 Diabetes Mellitus 13%
• HCT116 Cells 11%
• Colonic Neoplasms 8%
• Cytochrome P-450 CYP3A 6%
• Hep G2 Cells 6%
• Discoidin Domain Receptors 5%
• UGT1A8 UDP-glucuronosyltransferase 5%
• Drug Therapy 5%
• Vitronectin 4%
• Therapeutics 4%
• Glucose 3%
• Laminin 3%
• Liver Neoplasms 3%
• Fibronectins 3%
• Pancreatic Neoplasms 2%
• Tyrosine 2%
• Small Interfering RNA 2%
• Protein Isoforms 2%
• Lung Neoplasms 2%
• Radiotherapy 2%
• Phosphorylation 2%
• Enzymes 1%
• Kidney 1%
• Proteins 1%
• Neoplasms 0%

Chemical Compounds

• Dapagliflozin 100%
• Collagen 52%
• Cleavage 37%
• Tofogliflozin 20%
• Empagliflozin 18%
• Glucose 4%
• Small Interfering RNA 4%
• Fibronectin 3%
• Tyrosine 2%
• Protein 1%