Danio rerio αe-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αe-catenin

Phillip W. Miller, Sabine Pokutta, Agnidipta Ghosh, Steven C. Almo, William I. Weis, W. James Nelson, Adam V. Kwiatkowski

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: Mammalian αE-catenin is an allosterically regulated F-actin binding protein that inhibits the Arp2/3 complex. Results: D. rerio αE-catenin is a monomer that binds β-catenin and F-actin simultaneously but does not inhibit the Arp2/3 complex. Conclusion: D. rerio αE-catenin directly links the cadherin-catenin complex to F-actin. Significance: Core functions but not regulatory properties are conserved between β-catenin orthologs.

Original languageEnglish (US)
Pages (from-to)22324-22332
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
Publication statusPublished - Aug 2 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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