Danio rerio αe-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αe-catenin

Phillip W. Miller, Sabine Pokutta, Agnidipta Ghosh, Steven C. Almo, William I. Weis, W. James Nelson, Adam V. Kwiatkowski

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Mammalian αE-catenin is an allosterically regulated F-actin binding protein that inhibits the Arp2/3 complex. Results: D. rerio αE-catenin is a monomer that binds β-catenin and F-actin simultaneously but does not inhibit the Arp2/3 complex. Conclusion: D. rerio αE-catenin directly links the cadherin-catenin complex to F-actin. Significance: Core functions but not regulatory properties are conserved between β-catenin orthologs.

Original languageEnglish (US)
Pages (from-to)22324-22332
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
StatePublished - Aug 2 2013

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Catenins
Zebrafish
Actin-Related Protein 2-3 Complex
Actins
Cadherins
F-actin-binding proteins
Monomers

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Danio rerio αe-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αe-catenin. / Miller, Phillip W.; Pokutta, Sabine; Ghosh, Agnidipta; Almo, Steven C.; Weis, William I.; Nelson, W. James; Kwiatkowski, Adam V.

In: Journal of Biological Chemistry, Vol. 288, No. 31, 02.08.2013, p. 22324-22332.

Research output: Contribution to journalArticle

Miller, Phillip W. ; Pokutta, Sabine ; Ghosh, Agnidipta ; Almo, Steven C. ; Weis, William I. ; Nelson, W. James ; Kwiatkowski, Adam V. / Danio rerio αe-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αe-catenin. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 31. pp. 22324-22332.
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