TY - JOUR
T1 - Daily luteal serum and urinary hormone profiles in the menopause transition
T2 - Study of Women's Health Across the Nation
AU - Santoro, Nanette
AU - El Khoudary, Samar R.
AU - Nasr, Alexis
AU - Gold, Ellen B.
AU - Greendale, Gail
AU - Mcconnell, Dan
AU - Neal-Perry, Genevieve
AU - Pavlovic, Jelena
AU - Derby, Carol
AU - Crawford, Sybil
N1 - Publisher Copyright:
© 2020 by The North American Menopause Society.
PY - 2020
Y1 - 2020
N2 - Objective:To further characterize the endocrinology of the menopause transition, we sought to determine: whether relationships between urine and serum hormones are maintained as women enter their sixth decade; whether a single luteal phase serum progesterone (P) is reflective of integrated-luteal urinary pregnanediol glucuronide (uPdg); and whether serum P, like luteal uPdg, declines as women approach their final menses (FMP).Methods:The Study of Women's Health Across the Nation (SWAN) Daily Hormone Study's (DHS) is a community-based observational study. A subset of participants underwent a timed, luteal blood draw planned for cycle days 16 to 24 during the same month of DHS collection. Serum-luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol and P, and urine LH, FSH, estrone conjugates (E1c), and daily and integrated luteal uPdg were measured in 268 samples from 170 women. Serum/urine hormone associations were determined using Pearson's correlation and linear regression, adjusted for concurrent age, body mass index, smoking status, and race/ethnicity.Results:Pearson's r ranged from 0.573 (for LH) to 0.843 (for FSH) for serum/urine correlations. Integrated luteal uPdg weakly correlated with serum P (Pearson's r=0.26, P=0.004) and explained 7% of the variability in serum P in adjusted linear regression (total R2 0.09, P=0.002). Serum P demonstrated a marginally significant decline with approaching FMP in adjusted analysis (P=0.04).Conclusions:Urine and serum hormones maintain a close relationship in women into their sixth decade of life. Serum luteal P was weakly reflective of luteal Pdg excretion.
AB - Objective:To further characterize the endocrinology of the menopause transition, we sought to determine: whether relationships between urine and serum hormones are maintained as women enter their sixth decade; whether a single luteal phase serum progesterone (P) is reflective of integrated-luteal urinary pregnanediol glucuronide (uPdg); and whether serum P, like luteal uPdg, declines as women approach their final menses (FMP).Methods:The Study of Women's Health Across the Nation (SWAN) Daily Hormone Study's (DHS) is a community-based observational study. A subset of participants underwent a timed, luteal blood draw planned for cycle days 16 to 24 during the same month of DHS collection. Serum-luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol and P, and urine LH, FSH, estrone conjugates (E1c), and daily and integrated luteal uPdg were measured in 268 samples from 170 women. Serum/urine hormone associations were determined using Pearson's correlation and linear regression, adjusted for concurrent age, body mass index, smoking status, and race/ethnicity.Results:Pearson's r ranged from 0.573 (for LH) to 0.843 (for FSH) for serum/urine correlations. Integrated luteal uPdg weakly correlated with serum P (Pearson's r=0.26, P=0.004) and explained 7% of the variability in serum P in adjusted linear regression (total R2 0.09, P=0.002). Serum P demonstrated a marginally significant decline with approaching FMP in adjusted analysis (P=0.04).Conclusions:Urine and serum hormones maintain a close relationship in women into their sixth decade of life. Serum luteal P was weakly reflective of luteal Pdg excretion.
KW - Estradiol
KW - FSH
KW - LH
KW - Menstrual cycle
KW - Progesterone
KW - Reproductive aging
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U2 - 10.1097/GME.0000000000001453
DO - 10.1097/GME.0000000000001453
M3 - Article
C2 - 31794501
AN - SCOPUS:85078692191
SN - 1072-3714
VL - 27
SP - 127
EP - 133
JO - Menopause
JF - Menopause
IS - 2
ER -