Cytotoxicological effect of tebufenozide, an insect growth regulator (IGR): Stimulation of filamentous actin reorganization and enhancement of Hsp27 expression in drosophila Kc cells

Jee Na Hwang, Hwa Jin Jung, Young Rok Seo

Research output: Contribution to journalArticle

Abstract

The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and striking morphological changes including aggregation and elongation of the cells. In order to understand the cellular mechanism underlying the response of Drosophila cells to tebufenozide, immunofluorescence microscopy was performed. We found that treatment of Kc cells with tebufenozide enhanced the reorganization of f-actin and stimulated the expression of hsp27. These data suggest a possible association of filamentous actin (f-actin) and hsp27 in the cytotoxicological mechanisms of growth regulators in Drosophila cells.

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
JournalKorean Journal of Physiology and Pharmacology
Volume8
Issue number6
StatePublished - Dec 2004
Externally publishedYes

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Juvenile Hormones
Drosophila
Actins
Ecdysteroids
Cell Aggregation
Growth
Fluorescence Microscopy
tebufenozide

Keywords

  • Drosophila
  • F-actin
  • Hsp27
  • IGR
  • Tebufenozide

ASJC Scopus subject areas

  • Pharmacology
  • Physiology

Cite this

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abstract = "The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and striking morphological changes including aggregation and elongation of the cells. In order to understand the cellular mechanism underlying the response of Drosophila cells to tebufenozide, immunofluorescence microscopy was performed. We found that treatment of Kc cells with tebufenozide enhanced the reorganization of f-actin and stimulated the expression of hsp27. These data suggest a possible association of filamentous actin (f-actin) and hsp27 in the cytotoxicological mechanisms of growth regulators in Drosophila cells.",
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T1 - Cytotoxicological effect of tebufenozide, an insect growth regulator (IGR)

T2 - Stimulation of filamentous actin reorganization and enhancement of Hsp27 expression in drosophila Kc cells

AU - Hwang, Jee Na

AU - Jung, Hwa Jin

AU - Seo, Young Rok

PY - 2004/12

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N2 - The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and striking morphological changes including aggregation and elongation of the cells. In order to understand the cellular mechanism underlying the response of Drosophila cells to tebufenozide, immunofluorescence microscopy was performed. We found that treatment of Kc cells with tebufenozide enhanced the reorganization of f-actin and stimulated the expression of hsp27. These data suggest a possible association of filamentous actin (f-actin) and hsp27 in the cytotoxicological mechanisms of growth regulators in Drosophila cells.

AB - The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and striking morphological changes including aggregation and elongation of the cells. In order to understand the cellular mechanism underlying the response of Drosophila cells to tebufenozide, immunofluorescence microscopy was performed. We found that treatment of Kc cells with tebufenozide enhanced the reorganization of f-actin and stimulated the expression of hsp27. These data suggest a possible association of filamentous actin (f-actin) and hsp27 in the cytotoxicological mechanisms of growth regulators in Drosophila cells.

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