Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to acute allograft rejection

Elena Slavcheva, Efsevia Albanis, Qingsheng Jiao, Huong Tran, Carol Bodian, Richard Knight, Edgar Milford, Thomas Schiano, Yaron Tomer, Barbara Murphy

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background. Cytotoxic T-lymphocyte antigen 4 (CTLA4) has been shown to play a critical role in the down-regulation of the immune response. We retrospectively examined the association between acute rejection and two polymorphisms in the CTLA4 gene, the dinucleotide (AT)n repeat polymorphism in exon 3 and the single nucleotide polymorphism A/G at position 49 in exon 1, in a cohort of liver and kidney transplant recipients. Methods and Results. A total of 207 liver and 167 renal transplant recipients were analyzed. In the case of the (AT)n repeat polymorphism we found an increased incidence of acute rejection in association with allele 3 and 4 in both liver and kidney (P=0.002 and 0.05, respectively). In addition, in liver transplant recipients, allele 7 was associated with acute rejection independent of ethnicity (P

Original languageEnglish (US)
Pages (from-to)935-940
Number of pages6
JournalTransplantation
Volume72
Issue number5
StatePublished - Sep 15 2001
Externally publishedYes

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CTLA-4 Antigen
Allografts
Liver
Kidney
Genes
Exons
Alleles
Single Nucleotide Polymorphism
Down-Regulation
Incidence
Transplant Recipients

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Slavcheva, E., Albanis, E., Jiao, Q., Tran, H., Bodian, C., Knight, R., ... Murphy, B. (2001). Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to acute allograft rejection. Transplantation, 72(5), 935-940.

Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to acute allograft rejection. / Slavcheva, Elena; Albanis, Efsevia; Jiao, Qingsheng; Tran, Huong; Bodian, Carol; Knight, Richard; Milford, Edgar; Schiano, Thomas; Tomer, Yaron; Murphy, Barbara.

In: Transplantation, Vol. 72, No. 5, 15.09.2001, p. 935-940.

Research output: Contribution to journalArticle

Slavcheva, E, Albanis, E, Jiao, Q, Tran, H, Bodian, C, Knight, R, Milford, E, Schiano, T, Tomer, Y & Murphy, B 2001, 'Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to acute allograft rejection', Transplantation, vol. 72, no. 5, pp. 935-940.
Slavcheva E, Albanis E, Jiao Q, Tran H, Bodian C, Knight R et al. Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to acute allograft rejection. Transplantation. 2001 Sep 15;72(5):935-940.
Slavcheva, Elena ; Albanis, Efsevia ; Jiao, Qingsheng ; Tran, Huong ; Bodian, Carol ; Knight, Richard ; Milford, Edgar ; Schiano, Thomas ; Tomer, Yaron ; Murphy, Barbara. / Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to acute allograft rejection. In: Transplantation. 2001 ; Vol. 72, No. 5. pp. 935-940.
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AU - Albanis, Efsevia

AU - Jiao, Qingsheng

AU - Tran, Huong

AU - Bodian, Carol

AU - Knight, Richard

AU - Milford, Edgar

AU - Schiano, Thomas

AU - Tomer, Yaron

AU - Murphy, Barbara

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