Cytotoxic antibodies--valuable prognostic factor for long term kidney allograft survival.

Ana Moise, Daniela Nedelcu, Adela Toader, Mihaela Sora, Anca Tica, Denisa E. Ferastraoaru, Ileana Constantinescu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Since the first attempts of kidney transplant, the inflammation mediated by T lymphocytes was considered one of the most important processes implicated in graft rejection but, multiple acute and chronic graft rejects revealed that the inflammation process is not singular and humoral mechanisms may play a role in the development of chronic vascular rejection. We evaluated 500 Romanian patients registered on the kidney transplant waiting list. We performed anti-HLA class I and class II antibodies screening and identification. Laboratory tests were performed at Centre for Immunogenetics and Virology, Fundeni Clinical Institute, Bucharest, Romania. The methods used are represented by ELISA (GTI Diagnosis, USA) and Luminex (Tepnel, USA) RESULTS: pretransplant evaluation of the subjects illustrates that 145 patients (29%) have been sensitized and 355 patients (71%) have not been sensitized. The most frequent types of anti-HLA antibodies were A2 (13%), B42 (10%), DR7 and DR11 (13%). Post transplant, the most cases with de novo antibodies were observed in the first 6 months post transplantation. High serum levels of Il-2 Receptor, TNF-alpha and neopterin in post transplant sensitized patients were observed following de novo cytotoxic antibodies occurrence. post renal transplantation, patients present high risk in developing de novo cytotoxic antibodies, especially those who had HLA mismatch with the donor. These antibodies are predictors for acute graft rejection and for graft failure.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalJournal of medicine and life
Volume3
Issue number4
StatePublished - Oct 2010
Externally publishedYes

Fingerprint

Allografts
Transplants
Kidney
Antibodies
Graft Rejection
Inflammation
Neopterin
Immunogenetics
Romania
Virology
Waiting Lists
Immunoglobulin Isotypes
varespladib methyl
Kidney Transplantation
Blood Vessels
Anti-Idiotypic Antibodies
Tumor Necrosis Factor-alpha
Transplantation
Enzyme-Linked Immunosorbent Assay
Tissue Donors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Moise, A., Nedelcu, D., Toader, A., Sora, M., Tica, A., Ferastraoaru, D. E., & Constantinescu, I. (2010). Cytotoxic antibodies--valuable prognostic factor for long term kidney allograft survival. Journal of medicine and life, 3(4), 390-395.

Cytotoxic antibodies--valuable prognostic factor for long term kidney allograft survival. / Moise, Ana; Nedelcu, Daniela; Toader, Adela; Sora, Mihaela; Tica, Anca; Ferastraoaru, Denisa E.; Constantinescu, Ileana.

In: Journal of medicine and life, Vol. 3, No. 4, 10.2010, p. 390-395.

Research output: Contribution to journalArticle

Moise, A, Nedelcu, D, Toader, A, Sora, M, Tica, A, Ferastraoaru, DE & Constantinescu, I 2010, 'Cytotoxic antibodies--valuable prognostic factor for long term kidney allograft survival.', Journal of medicine and life, vol. 3, no. 4, pp. 390-395.
Moise, Ana ; Nedelcu, Daniela ; Toader, Adela ; Sora, Mihaela ; Tica, Anca ; Ferastraoaru, Denisa E. ; Constantinescu, Ileana. / Cytotoxic antibodies--valuable prognostic factor for long term kidney allograft survival. In: Journal of medicine and life. 2010 ; Vol. 3, No. 4. pp. 390-395.
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