Cytoreduction Results in High Perioperative Mortality and Decreased Survival in Patients Undergoing Pancreatectomy for Neuroendocrine Tumors of the Pancreas

Mark Bloomston, Peter Muscarella, Manisha H. Shah, Wendy L. Frankel, Osama Al-Saif, Edward W. Martin, E. Christopher Ellison

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We reviewed our experience with pancreatectomy for neuroendocrine tumors (NE) to determine outcomes after R0/R1 or R2 resection and compare them to patients in whom resection was not attempted. Data were reviewed for all patients presenting with NE tumors of the pancreas between 1990 and 2005. Kaplan-Meier survival curves were compared by log-rank analysis. Multivariate analysis was completed using Cox proportional hazards to identify risk factors for poor survival after resection. Of 120 patients, 65 (54%) had functional tumors. Resection was undertaken in 83: distal pancreatectomy in 41, pancreaticoduodenectomy in 27, enucleation in 14, and central pancreatectomy in 1. Survival was significantly longer after resection (91 months versus 24, P < 0.001). R0/R1 resection was accomplished in 64 (77%) and resulted in lower perioperative mortality (2% versus 21%, P < 0.01) and longer survival (112 months versus 24, P < 0.001) compared to R2 resection. Survival after R2 resection was no better than after no resection. Factors predictive of decreased survival were moderate/poor differentiation, R2 resection, and high-risk features. Long-term survival is possible following complete resection for NE tumors of the pancreas. However, cytoreduction resulting in incomplete tumor removal carries significant perioperative mortality without long-term survival benefit and should be discouraged.

Original languageEnglish (US)
Pages (from-to)1361-1370
Number of pages10
JournalJournal of Gastrointestinal Surgery
Volume10
Issue number10
DOIs
StatePublished - Dec 2006
Externally publishedYes

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Pancreatectomy
Neuroendocrine Tumors
Pancreas
Survival
Mortality
Neoplasms
Pancreaticoduodenectomy
Kaplan-Meier Estimate
Multivariate Analysis

Keywords

  • endocrine
  • islet cell carcinoma
  • Neuroendocrine
  • pancreas
  • survival

ASJC Scopus subject areas

  • Surgery

Cite this

Cytoreduction Results in High Perioperative Mortality and Decreased Survival in Patients Undergoing Pancreatectomy for Neuroendocrine Tumors of the Pancreas. / Bloomston, Mark; Muscarella, Peter; Shah, Manisha H.; Frankel, Wendy L.; Al-Saif, Osama; Martin, Edward W.; Ellison, E. Christopher.

In: Journal of Gastrointestinal Surgery, Vol. 10, No. 10, 12.2006, p. 1361-1370.

Research output: Contribution to journalArticle

Bloomston, Mark ; Muscarella, Peter ; Shah, Manisha H. ; Frankel, Wendy L. ; Al-Saif, Osama ; Martin, Edward W. ; Ellison, E. Christopher. / Cytoreduction Results in High Perioperative Mortality and Decreased Survival in Patients Undergoing Pancreatectomy for Neuroendocrine Tumors of the Pancreas. In: Journal of Gastrointestinal Surgery. 2006 ; Vol. 10, No. 10. pp. 1361-1370.
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