Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs

Masahiko Sugita, Robin M. Jackman, Elly Van Donselaar, Samuel M. Behar, Rick A. Rogers, Peter J. Peters, Michael B. Brenner, Steven A. Porcelli

Research output: Contribution to journalArticlepeer-review

201 Scopus citations


CD1 proteins have been implicated as antigen-presenting molecules for T cell-mediated immune responses, but their intracellular localization and trafficking remain uncharacterized. CD1b, a member of this family that presents microbial lipid antigens of exogenous origin, was found to localize to endocytic compartments that included the same specialized subset of endosomes in which major histocompatibility complex (MHC) class II molecules are proposed to bind endocytosed antigens. Unlike MHC class II molecules, which traffic to antigen-loading endosomal compartments [MHC class II compartments (MIICs)] primarily as a consequence of their association with the invariant chain, localization of CD1b to these compartments was dependent on a tyrosine-based motif in its own cytoplasmic tail.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
Issue number5273
StatePublished - Jul 19 1996
Externally publishedYes

ASJC Scopus subject areas

  • General


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