Cytopathology of anaplastic carcinoma of the pancreas

Review of a rare entity and description of a variant with signet ring cell features

Siba El Hussein, Samer N. Khader

Research output: Contribution to journalArticle

Abstract

Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive variant of pancreatic ductal adenocarcinoma (PDAC). Several studies have attempted to characterize this subtype through case series or single case reports; however, ACP remains underrecognized by cytopathologists in particular, and often lumped under the umbrella of classic PDAC. Here, we review the most up to date data that literature provides about ACP, to bring familiarity with this entity to the cytopathology practice, and to elucidate the role cytopathologists can play in recognizing and diagnosing this subtype on pancreatic aspiration biopsy, before surgical resection. We also describe a rare case of ACP, demonstrating signet ring cell features, that was diagnosed on fine needle aspiration of a pancreatic mass.

Original languageEnglish (US)
JournalDiagnostic Cytopathology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Pancreas
Carcinoma
Adenocarcinoma
Needle Biopsy
Fine Needle Biopsy

Keywords

  • anaplastic carcinoma of the pancreas
  • cytopathology
  • FNA
  • pleomorphic carcinoma of the pancreas
  • signet ring cell features

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

@article{64e7d6b6913e47a4847f8e74256f5573,
title = "Cytopathology of anaplastic carcinoma of the pancreas: Review of a rare entity and description of a variant with signet ring cell features",
abstract = "Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive variant of pancreatic ductal adenocarcinoma (PDAC). Several studies have attempted to characterize this subtype through case series or single case reports; however, ACP remains underrecognized by cytopathologists in particular, and often lumped under the umbrella of classic PDAC. Here, we review the most up to date data that literature provides about ACP, to bring familiarity with this entity to the cytopathology practice, and to elucidate the role cytopathologists can play in recognizing and diagnosing this subtype on pancreatic aspiration biopsy, before surgical resection. We also describe a rare case of ACP, demonstrating signet ring cell features, that was diagnosed on fine needle aspiration of a pancreatic mass.",
keywords = "anaplastic carcinoma of the pancreas, cytopathology, FNA, pleomorphic carcinoma of the pancreas, signet ring cell features",
author = "{El Hussein}, Siba and Khader, {Samer N.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/dc.24263",
language = "English (US)",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Cytopathology of anaplastic carcinoma of the pancreas

T2 - Review of a rare entity and description of a variant with signet ring cell features

AU - El Hussein, Siba

AU - Khader, Samer N.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive variant of pancreatic ductal adenocarcinoma (PDAC). Several studies have attempted to characterize this subtype through case series or single case reports; however, ACP remains underrecognized by cytopathologists in particular, and often lumped under the umbrella of classic PDAC. Here, we review the most up to date data that literature provides about ACP, to bring familiarity with this entity to the cytopathology practice, and to elucidate the role cytopathologists can play in recognizing and diagnosing this subtype on pancreatic aspiration biopsy, before surgical resection. We also describe a rare case of ACP, demonstrating signet ring cell features, that was diagnosed on fine needle aspiration of a pancreatic mass.

AB - Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive variant of pancreatic ductal adenocarcinoma (PDAC). Several studies have attempted to characterize this subtype through case series or single case reports; however, ACP remains underrecognized by cytopathologists in particular, and often lumped under the umbrella of classic PDAC. Here, we review the most up to date data that literature provides about ACP, to bring familiarity with this entity to the cytopathology practice, and to elucidate the role cytopathologists can play in recognizing and diagnosing this subtype on pancreatic aspiration biopsy, before surgical resection. We also describe a rare case of ACP, demonstrating signet ring cell features, that was diagnosed on fine needle aspiration of a pancreatic mass.

KW - anaplastic carcinoma of the pancreas

KW - cytopathology

KW - FNA

KW - pleomorphic carcinoma of the pancreas

KW - signet ring cell features

UR - http://www.scopus.com/inward/record.url?scp=85068341672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068341672&partnerID=8YFLogxK

U2 - 10.1002/dc.24263

DO - 10.1002/dc.24263

M3 - Article

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

ER -