Cytokine-induced inflammation in the central nervous system revisited

James A. Martiney, Carolyn Cuff, Mona Litwak, Joan Berman, Celia F. Brosnan

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Cytokines play an essential role as mediators of the immune response. They usually function as part of a network of interactive signals that either activate, enhance, or inhibit the ensuing reaction. An important contribution of this cytokine cascade is the induction of an inflammatory response that recruits and activates subsets of leukocytes that function as effector cells in the response to the sensitizing antigen. Proinflammatory cytokines activate endothelial cells (EC) to express adhesion molecules and induce the release of members of the chemokine family, thus focusing and directing the inflammatory response to sites of antigen recognition. However, the vasculature of the central nervous system (CNS) is highly specialized and restricts the access of components of the immune system to the CNS compartment. In this review, we address the question as to whether endothelial cells in the CNS respond differently to specific cytokines known to induce either a proinflammatory effect or a regulatory effect in systemic vascular beds.

Original languageEnglish (US)
Pages (from-to)349-359
Number of pages11
JournalNeurochemical Research
Volume23
Issue number3
DOIs
StatePublished - Mar 24 1998

Keywords

  • Adhesion molecules
  • CNS inflammation
  • Chemokines
  • Cytokines
  • Neuroimmunology
  • Review

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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