Cytokine-induced inflammation in the central nervous system revisited

James A. Martiney, Carolyn Cuff, Mona Litwak, Joan W. Berman, Celia F. Brosnan

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Cytokines play an essential role as mediators of the immune response. They usually function as part of a network of interactive signals that either activate, enhance, or inhibit the ensuing reaction. An important contribution of this cytokine cascade is the induction of an inflammatory response that recruits and activates subsets of leukocytes that function as effector cells in the response to the sensitizing antigen. Proinflammatory cytokines activate endothelial cells (EC) to express adhesion molecules and induce the release of members of the chemokine family, thus focusing and directing the inflammatory response to sites of antigen recognition. However, the vasculature of the central nervous system (CNS) is highly specialized and restricts the access of components of the immune system to the CNS compartment. In this review, we address the question as to whether endothelial cells in the CNS respond differently to specific cytokines known to induce either a proinflammatory effect or a regulatory effect in systemic vascular beds.

Original languageEnglish (US)
Pages (from-to)349-359
Number of pages11
JournalNeurochemical Research
Volume23
Issue number3
DOIs
StatePublished - 1998

Fingerprint

Neurology
Central Nervous System
Cytokines
Inflammation
Endothelial cells
Endothelial Cells
Antigens
Immune system
Chemokines
Blood Vessels
Immune System
Leukocytes
Adhesion
Molecules

Keywords

  • Adhesion molecules
  • Chemokines
  • CNS inflammation
  • Cytokines
  • Neuroimmunology
  • Review

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Cytokine-induced inflammation in the central nervous system revisited. / Martiney, James A.; Cuff, Carolyn; Litwak, Mona; Berman, Joan W.; Brosnan, Celia F.

In: Neurochemical Research, Vol. 23, No. 3, 1998, p. 349-359.

Research output: Contribution to journalArticle

Martiney, James A. ; Cuff, Carolyn ; Litwak, Mona ; Berman, Joan W. ; Brosnan, Celia F. / Cytokine-induced inflammation in the central nervous system revisited. In: Neurochemical Research. 1998 ; Vol. 23, No. 3. pp. 349-359.
@article{0e81d17e3b4045f1b22cda76f4335238,
title = "Cytokine-induced inflammation in the central nervous system revisited",
abstract = "Cytokines play an essential role as mediators of the immune response. They usually function as part of a network of interactive signals that either activate, enhance, or inhibit the ensuing reaction. An important contribution of this cytokine cascade is the induction of an inflammatory response that recruits and activates subsets of leukocytes that function as effector cells in the response to the sensitizing antigen. Proinflammatory cytokines activate endothelial cells (EC) to express adhesion molecules and induce the release of members of the chemokine family, thus focusing and directing the inflammatory response to sites of antigen recognition. However, the vasculature of the central nervous system (CNS) is highly specialized and restricts the access of components of the immune system to the CNS compartment. In this review, we address the question as to whether endothelial cells in the CNS respond differently to specific cytokines known to induce either a proinflammatory effect or a regulatory effect in systemic vascular beds.",
keywords = "Adhesion molecules, Chemokines, CNS inflammation, Cytokines, Neuroimmunology, Review",
author = "Martiney, {James A.} and Carolyn Cuff and Mona Litwak and Berman, {Joan W.} and Brosnan, {Celia F.}",
year = "1998",
doi = "10.1023/A:1022457500700",
language = "English (US)",
volume = "23",
pages = "349--359",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Cytokine-induced inflammation in the central nervous system revisited

AU - Martiney, James A.

AU - Cuff, Carolyn

AU - Litwak, Mona

AU - Berman, Joan W.

AU - Brosnan, Celia F.

PY - 1998

Y1 - 1998

N2 - Cytokines play an essential role as mediators of the immune response. They usually function as part of a network of interactive signals that either activate, enhance, or inhibit the ensuing reaction. An important contribution of this cytokine cascade is the induction of an inflammatory response that recruits and activates subsets of leukocytes that function as effector cells in the response to the sensitizing antigen. Proinflammatory cytokines activate endothelial cells (EC) to express adhesion molecules and induce the release of members of the chemokine family, thus focusing and directing the inflammatory response to sites of antigen recognition. However, the vasculature of the central nervous system (CNS) is highly specialized and restricts the access of components of the immune system to the CNS compartment. In this review, we address the question as to whether endothelial cells in the CNS respond differently to specific cytokines known to induce either a proinflammatory effect or a regulatory effect in systemic vascular beds.

AB - Cytokines play an essential role as mediators of the immune response. They usually function as part of a network of interactive signals that either activate, enhance, or inhibit the ensuing reaction. An important contribution of this cytokine cascade is the induction of an inflammatory response that recruits and activates subsets of leukocytes that function as effector cells in the response to the sensitizing antigen. Proinflammatory cytokines activate endothelial cells (EC) to express adhesion molecules and induce the release of members of the chemokine family, thus focusing and directing the inflammatory response to sites of antigen recognition. However, the vasculature of the central nervous system (CNS) is highly specialized and restricts the access of components of the immune system to the CNS compartment. In this review, we address the question as to whether endothelial cells in the CNS respond differently to specific cytokines known to induce either a proinflammatory effect or a regulatory effect in systemic vascular beds.

KW - Adhesion molecules

KW - Chemokines

KW - CNS inflammation

KW - Cytokines

KW - Neuroimmunology

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=0031909986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031909986&partnerID=8YFLogxK

U2 - 10.1023/A:1022457500700

DO - 10.1023/A:1022457500700

M3 - Article

C2 - 9482247

AN - SCOPUS:0031909986

VL - 23

SP - 349

EP - 359

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 3

ER -