Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease

Michael K. Racke, Adriana Bonomo, Dorothy E. Scott, Barbara Cannella, Alan Levine, Cedric S. Raine, Ethan M. Shevach, Martin Röcken

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Abstract

The properties and outcome of an immune response are best predicted by the lymphokine phenotype of the responding T cells. Cytokines produced by CD4+ T helper type 1 (Th1) T cells mediate delayed type hypersensitivity (DTH) and inflammatory responses, whereas cytokines produced by Th2 T cells mediate helper T cell functions for antibody production. To determine whether induction of Th2-like cells would modulate an inflammatory response, interleukin 4 (IL-4) was administered to animals with experimental allergic encephalomyelitis (EAE), a prototypic autoimmune disease produced by Th1- like T cells specific for myelin basic protein (MBP). IL-4 treatment resulted in amelioration of clinical disease, the induction of MBP-specific Th2 cells, diminished demyelination, and inhibition of the synthesis of inflammatory cytokines in the central nervous system (CNS). Modulation of an immune response from one dominated by excessive activity of Th1-like T cells to one dominated by the protective cytokines produced by Th2-like T cells may have applicability to the therapy of certain human autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)1961-1966
Number of pages6
JournalJournal of Experimental Medicine
Volume180
Issue number5
DOIs
StatePublished - Nov 1 1994

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Th2 Cells
Th1 Cells
Autoimmune Diseases
Cytokines
Myelin Basic Protein
T-Lymphocytes
Interleukin-4
Autoimmune Experimental Encephalomyelitis
Lymphokines
Delayed Hypersensitivity
Demyelinating Diseases
Therapeutics
Helper-Inducer T-Lymphocytes
Antibody Formation
Central Nervous System
Phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Racke, M. K., Bonomo, A., Scott, D. E., Cannella, B., Levine, A., Raine, C. S., ... Röcken, M. (1994). Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. Journal of Experimental Medicine, 180(5), 1961-1966. https://doi.org/10.1084/jem.180.5.1961

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. / Racke, Michael K.; Bonomo, Adriana; Scott, Dorothy E.; Cannella, Barbara; Levine, Alan; Raine, Cedric S.; Shevach, Ethan M.; Röcken, Martin.

In: Journal of Experimental Medicine, Vol. 180, No. 5, 01.11.1994, p. 1961-1966.

Research output: Contribution to journalArticle

Racke, MK, Bonomo, A, Scott, DE, Cannella, B, Levine, A, Raine, CS, Shevach, EM & Röcken, M 1994, 'Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease', Journal of Experimental Medicine, vol. 180, no. 5, pp. 1961-1966. https://doi.org/10.1084/jem.180.5.1961
Racke, Michael K. ; Bonomo, Adriana ; Scott, Dorothy E. ; Cannella, Barbara ; Levine, Alan ; Raine, Cedric S. ; Shevach, Ethan M. ; Röcken, Martin. / Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. In: Journal of Experimental Medicine. 1994 ; Vol. 180, No. 5. pp. 1961-1966.
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