Cytogenetic abnormalities in products of conception: A relationship revisited

Rushdia Z. Yusuf, Rizwan C. Naeem

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objectives: Cytogenetic evaluation of product of conception (POC) is essential to determine the cause of pregnancy loss and aid the prenatal diagnosis of subsequent pregnancies. The purpose of this study is twofold. (1) To profile cytogenctic abnormalities, their relationship with maternal and gestational age and analyze sex ratios in our case series of 2052 consecutive samples of POC referred to the Baystate Medical Center, Laboratory Genetics between January 1992 and January 1999. (2) To present a comprehensive review of such data published in the last 15 years, in order to study temporal differences in the above parameters and make this information readily available for cytogeneticists and genetic counselors. Materials and Methods: Data was entered and analyzed in Epi Info version 6.0 using the Z-test, chi-square test of significance and linear correlation coefficient. Results and Conclusions: The profile of cytogenetic abnormalities detected in POC has not changes significantly over time. The mean maternal age in our study (overall and for trisomies) was higher than that reported previously, which is consistent with the noted trend of increasing age at pregnancy in recent years. Our study provides evidence that abnormal karyotypes are aborted earlier and that tetraploidies have the least survival amongst all abnormalities. The higher mean gestational age for trisomic abortions in our study, as compared with previously reported figures, can be attributed to the increasing practice of active maternal screening with subsequent therapeutic abortions. Analysis of sex ratios may reaffirm a female specific developmental disadvantage in early stages of pregnancy.

Original languageEnglish (US)
Pages (from-to)88-96
Number of pages9
JournalAmerican Journal of Reproductive Immunology
Volume52
Issue number1
StatePublished - Jul 2004
Externally publishedYes

Fingerprint

Chromosome Aberrations
Pregnancy
Sex Ratio
Maternal Age
Gestational Age
Therapeutic Abortion
Abnormal Karyotype
Tetraploidy
Trisomy
Chi-Square Distribution
Prenatal Diagnosis
Cytogenetics
Mothers

Keywords

  • Chromosome abnormalities
  • Fetal Karyotype
  • Spontaneous miscarriages

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynecology

Cite this

Cytogenetic abnormalities in products of conception : A relationship revisited. / Yusuf, Rushdia Z.; Naeem, Rizwan C.

In: American Journal of Reproductive Immunology, Vol. 52, No. 1, 07.2004, p. 88-96.

Research output: Contribution to journalArticle

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