Cystic disease of the kidney

Patricia D. Wilson, Beatrice Goilav

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

This review focuses on the mechanisms that underlie the development of human renal cystic diseases. A pathological, clinical, and pathophysiological overview is given. Initial analysis of the cell biology of inappropriate hyperproliferation accompanied by fluid secretion of cyst-lining epithelia has been followed by the elucidation of fundamental defects in epithelial polarity, cell-matrix and cell-cell interactions, and apoptosis, all of which are discussed. Identification of the genes and proteins responsible for several renal cystic diseases has led to a more complete understanding of defects in renal developmental programming, differentiation, and morphogenesis, all of which underlie cystic diseases of the kidney.

Original languageEnglish (US)
Pages (from-to)341-368
Number of pages28
JournalAnnual Review of Pathology
Volume2
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Cystic Kidney Diseases
Fluids and Secretions
Human Development
Morphogenesis
Cell Communication
Cell Biology
Cysts
Epithelium
Epithelial Cells
Apoptosis
Kidney
Proteins

Keywords

  • Autosomal polycystic kidney disease
  • Cilia
  • Differentiation
  • Epithelial polarity
  • Genes
  • Pathophysiology
  • Proteins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cystic disease of the kidney. / Wilson, Patricia D.; Goilav, Beatrice.

In: Annual Review of Pathology, Vol. 2, 2007, p. 341-368.

Research output: Contribution to journalArticle

Wilson, Patricia D. ; Goilav, Beatrice. / Cystic disease of the kidney. In: Annual Review of Pathology. 2007 ; Vol. 2. pp. 341-368.
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