Cyclophosphamide treatment of lymphoma during third trimester of pregnancy

John A. Hardin

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Burkitťs lymphoma was diagnosed in a patient during the third trimester of pregnancy. Treatment was high-dose, intermittent cyclophosphamide initially gave a good response which permitted the pregnancy to be carried to term. The infant was normal at birth and had a normal white blood cell count and hematocrit, despite leukopenia in the mother, and he still remains normal at the age of 12 months. Results in this patient and a survey of reported cases in which cyclophosphamide was administered during pregnancy lead to the conclusions that low-dose oral therapy is the least hazardous regimen early in pregnancy while late in pregnancy, large doses administered intravenously may be tolerated without fetal damage.

Original languageEnglish (US)
Pages (from-to)850-851
Number of pages2
JournalObstetrics and gynecology
Volume39
Issue number6
StatePublished - Jun 1972

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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