Cyclophosphamide in the treatment of toxic epidermal necrolysis

Nikolaos G. Frangogiannis, Illya Boridy, Mobeen Mazhar, Rajy Mathews, Subroto Gangopadhyay, Thomas Cate

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Abstract

A patient with non-small cell lung carcinoma and recent radiotherapy for brain metastases developed toxic epidermal necrolysis (TEN) shortly after therapy with phenytoin was initiated for a seizure. Exfoliation progressed to involve 90% of her body surface despite treatment with high-dose corticosteroids for 5 days, but sloughing and systemic toxicity ceased within 2 days of initiating therapy with intravenous cyclophosphamide (300 mg/day). Reepithelialization rapidly followed. This experience and the reports of others suggest that intravenous cyclophosphamide is helpful in the treatment of TEN.

Original languageEnglish (US)
Pages (from-to)1001-1003
Number of pages3
JournalSouthern Medical Journal
Volume89
Issue number10
DOIs
Publication statusPublished - Oct 29 1996
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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