TY - JOUR
T1 - Cyclophosphamide in the treatment of toxic epidermal necrolysis
AU - Frangogiannis, Nikolaos G.
AU - Boridy, Illya
AU - Mazhar, Mobeen
AU - Mathews, Rajy
AU - Gangopadhyay, Subroto
AU - Cate, Thomas
PY - 1996
Y1 - 1996
N2 - A patient with non-small cell lung carcinoma and recent radiotherapy for brain metastases developed toxic epidermal necrolysis (TEN) shortly after therapy with phenytoin was initiated for a seizure. Exfoliation progressed to involve 90% of her body surface despite treatment with high-dose corticosteroids for 5 days, but sloughing and systemic toxicity ceased within 2 days of initiating therapy with intravenous cyclophosphamide (300 mg/day). Reepithelialization rapidly followed. This experience and the reports of others suggest that intravenous cyclophosphamide is helpful in the treatment of TEN.
AB - A patient with non-small cell lung carcinoma and recent radiotherapy for brain metastases developed toxic epidermal necrolysis (TEN) shortly after therapy with phenytoin was initiated for a seizure. Exfoliation progressed to involve 90% of her body surface despite treatment with high-dose corticosteroids for 5 days, but sloughing and systemic toxicity ceased within 2 days of initiating therapy with intravenous cyclophosphamide (300 mg/day). Reepithelialization rapidly followed. This experience and the reports of others suggest that intravenous cyclophosphamide is helpful in the treatment of TEN.
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U2 - 10.1097/00007611-199610000-00015
DO - 10.1097/00007611-199610000-00015
M3 - Article
C2 - 8865797
AN - SCOPUS:0029859571
SN - 0038-4348
VL - 89
SP - 1001
EP - 1003
JO - Southern Medical Journal
JF - Southern Medical Journal
IS - 10
ER -