Cyclic AMP derivatives injected into the inferior colliculus induce audiogenic seizure-like phenomena in normal rats

Nandor Ludvig, Solomon L. Moshé

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Microinjection of 10 μg of either dibutyryl cyclic AMP or 8-bromo-cyclic AMP into the inferior colliculus of normal rats induced audiogenic seizure-like phenomena, which were intensified by sound stimulation. Microinjection of either cyclic AMP derivatives into areas surrounding the inferior colliculus or in the substantia nigra-region did not induce any such effects. These data suggest that there may be a close relationship between audiogenic seizures and cyclic AMP metabolism of the inferior colliculus.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalBrain Research
Volume437
Issue number1
DOIs
StatePublished - Dec 22 1987

Keywords

  • Audiogenic seizure
  • Conculsion
  • Cyclic AMP
  • Ingerior colliculus
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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