TY - JOUR
T1 - Cushing syndrome from percutaneous absorption of 1% hydrocortisone ointment in Netherton syndrome
AU - Halverstam, Caroline P.
AU - Vachharajani, Akshaya
AU - Mallory, Susan Bayliss
PY - 2007/1
Y1 - 2007/1
N2 - Netherton syndrome is a congenital skin disease associated with decreased skin barrier function and increased percutaneous absorption. We report an 11-year-old boy with Netherton syndrome who developed Cushing syndrome after application of 1% hydrocortisone ointment to his entire body for more than 1 year. This presentation illustrates that even low-potency steroid ointments should be used with caution in Netherton syndrome and warns about the use of long-term topical medications with potential systemic side effects when used in large quantities in any chronic skin disease.
AB - Netherton syndrome is a congenital skin disease associated with decreased skin barrier function and increased percutaneous absorption. We report an 11-year-old boy with Netherton syndrome who developed Cushing syndrome after application of 1% hydrocortisone ointment to his entire body for more than 1 year. This presentation illustrates that even low-potency steroid ointments should be used with caution in Netherton syndrome and warns about the use of long-term topical medications with potential systemic side effects when used in large quantities in any chronic skin disease.
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U2 - 10.1111/j.1525-1470.2007.00331.x
DO - 10.1111/j.1525-1470.2007.00331.x
M3 - Article
C2 - 17300648
AN - SCOPUS:33846990435
SN - 0736-8046
VL - 24
SP - 42
EP - 45
JO - Pediatric Dermatology
JF - Pediatric Dermatology
IS - 1
ER -