Cushing syndrome from percutaneous absorption of 1% hydrocortisone ointment in Netherton syndrome

Caroline P. Halverstam, Akshaya Vachharajani, Susan Bayliss Mallory

Research output: Contribution to journalArticle

27 Scopus citations


Netherton syndrome is a congenital skin disease associated with decreased skin barrier function and increased percutaneous absorption. We report an 11-year-old boy with Netherton syndrome who developed Cushing syndrome after application of 1% hydrocortisone ointment to his entire body for more than 1 year. This presentation illustrates that even low-potency steroid ointments should be used with caution in Netherton syndrome and warns about the use of long-term topical medications with potential systemic side effects when used in large quantities in any chronic skin disease.

Original languageEnglish (US)
Pages (from-to)42-45
Number of pages4
JournalPediatric Dermatology
Issue number1
Publication statusPublished - Jan 1 2007
Externally publishedYes


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

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