Current treatment of juvenile rheumatoid arthritis

Norman T. Ilowite

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

Prognostic factors in juvenile rheumatoid arthritis (JRA) include polyarticular onset, polyarticular disease course, and rheumatoid factor positivity; in the systemic onset subtype, persistence of systemic features at 6 months after onset confers a worse prognosis. Timely diagnosis and appropriate aggressive treatment of patients with poor prognostic features improve quality of life and outcome. After nonsteroidal anti-inflammatory drugs, methotrexate is the most commonly used second-line agent. However, approximately one third of patients do not respond to methotrexate adequately. Randomized, placebo-controlled, clinical trials in patients with JRA are few, but one such trial with the tumor necrosis factor inhibitor etanercept shows that this drug is effective and well-tolerated. Other recently approved agents for rheumatoid arthritis, including infliximab, leflunomide, celecoxib, and rofecoxib, have not been adequately studied in pediatric patients, and the role of these agents in children with JRA remains to be determined.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalPediatrics
Volume109
Issue number1
DOIs
StatePublished - Jan 19 2002

Keywords

  • Antirheumatic agents
  • Disease-modifying antirheumatic drugs
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Current treatment of juvenile rheumatoid arthritis'. Together they form a unique fingerprint.

  • Cite this