Current state of pediatric sarcoma biology and opportunities for future discovery

A report from the sarcoma translational research workshop

Pooja Hingorani, Katherine Janeway, Brian D. Crompton, Cigall Kadoch, Crystal L. Mackall, Javed Khan, Jack F. Shern, Joshua Schiffman, Lisa Mirabello, Sharon A. Savage, Marc Ladanyi, Paul Meltzer, Carol J. Bult, Peter C. Adamson, Philip J. Lupo, Rajen Mody, Steven G. DuBois, D. Williams Parsons, Chand Khanna, Ching Lau & 9 others Douglas S. Hawkins, R. Lor Randall, Malcolm Smith, Poul H. Sorensen, Sharon E. Plon, Stephen X. Skapek, Stephen Lessnick, Richard Gorlick, Damon R. Reed

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time. However, much remains to be accomplished in this arena especially with regard to translating all of this new knowledge to the bedside. To this end, a meeting was convened in Philadelphia, PA, on April 18, 2015 sponsored by the QuadW foundation, Children's Oncology Group and CureSearch for Children's Cancer that brought together sarcoma clinicians and scientists from North America to review the current state of pediatric sarcoma biology and ongoing/planned genomics based clinical trials in an effort to identify and bridge knowledge gaps that continue to exist at present. At the conclusion of the workshop, three key objectives that would significantly further our understanding of sarcoma were identified and a proposal was put forward to develop an all-encompassing pediatric sarcoma biology protocol that would address these specific needs. This review summarizes the proceedings of the workshop.

Original languageEnglish (US)
Pages (from-to)182-194
Number of pages13
JournalCancer genetics
Volume209
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Translational Medical Research
Sarcoma
Pediatrics
Education
Neoplasms
North America
Genomics
Transcriptome
Clinical Trials
Genome
Technology
Bone and Bones
Drug Therapy

Keywords

  • Genomics
  • Molecular profiling
  • Patient derived xenografts
  • Pediatric sarcoma
  • Precision medicine
  • Sarcoma biology

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Current state of pediatric sarcoma biology and opportunities for future discovery : A report from the sarcoma translational research workshop. / Hingorani, Pooja; Janeway, Katherine; Crompton, Brian D.; Kadoch, Cigall; Mackall, Crystal L.; Khan, Javed; Shern, Jack F.; Schiffman, Joshua; Mirabello, Lisa; Savage, Sharon A.; Ladanyi, Marc; Meltzer, Paul; Bult, Carol J.; Adamson, Peter C.; Lupo, Philip J.; Mody, Rajen; DuBois, Steven G.; Parsons, D. Williams; Khanna, Chand; Lau, Ching; Hawkins, Douglas S.; Randall, R. Lor; Smith, Malcolm; Sorensen, Poul H.; Plon, Sharon E.; Skapek, Stephen X.; Lessnick, Stephen; Gorlick, Richard; Reed, Damon R.

In: Cancer genetics, Vol. 209, No. 5, 01.05.2016, p. 182-194.

Research output: Contribution to journalReview article

Hingorani, P, Janeway, K, Crompton, BD, Kadoch, C, Mackall, CL, Khan, J, Shern, JF, Schiffman, J, Mirabello, L, Savage, SA, Ladanyi, M, Meltzer, P, Bult, CJ, Adamson, PC, Lupo, PJ, Mody, R, DuBois, SG, Parsons, DW, Khanna, C, Lau, C, Hawkins, DS, Randall, RL, Smith, M, Sorensen, PH, Plon, SE, Skapek, SX, Lessnick, S, Gorlick, R & Reed, DR 2016, 'Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop', Cancer genetics, vol. 209, no. 5, pp. 182-194. https://doi.org/10.1016/j.cancergen.2016.03.004
Hingorani, Pooja ; Janeway, Katherine ; Crompton, Brian D. ; Kadoch, Cigall ; Mackall, Crystal L. ; Khan, Javed ; Shern, Jack F. ; Schiffman, Joshua ; Mirabello, Lisa ; Savage, Sharon A. ; Ladanyi, Marc ; Meltzer, Paul ; Bult, Carol J. ; Adamson, Peter C. ; Lupo, Philip J. ; Mody, Rajen ; DuBois, Steven G. ; Parsons, D. Williams ; Khanna, Chand ; Lau, Ching ; Hawkins, Douglas S. ; Randall, R. Lor ; Smith, Malcolm ; Sorensen, Poul H. ; Plon, Sharon E. ; Skapek, Stephen X. ; Lessnick, Stephen ; Gorlick, Richard ; Reed, Damon R. / Current state of pediatric sarcoma biology and opportunities for future discovery : A report from the sarcoma translational research workshop. In: Cancer genetics. 2016 ; Vol. 209, No. 5. pp. 182-194.
@article{88645357bc724f4fb9c67a8b3df20188,
title = "Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop",
abstract = "Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time. However, much remains to be accomplished in this arena especially with regard to translating all of this new knowledge to the bedside. To this end, a meeting was convened in Philadelphia, PA, on April 18, 2015 sponsored by the QuadW foundation, Children's Oncology Group and CureSearch for Children's Cancer that brought together sarcoma clinicians and scientists from North America to review the current state of pediatric sarcoma biology and ongoing/planned genomics based clinical trials in an effort to identify and bridge knowledge gaps that continue to exist at present. At the conclusion of the workshop, three key objectives that would significantly further our understanding of sarcoma were identified and a proposal was put forward to develop an all-encompassing pediatric sarcoma biology protocol that would address these specific needs. This review summarizes the proceedings of the workshop.",
keywords = "Genomics, Molecular profiling, Patient derived xenografts, Pediatric sarcoma, Precision medicine, Sarcoma biology",
author = "Pooja Hingorani and Katherine Janeway and Crompton, {Brian D.} and Cigall Kadoch and Mackall, {Crystal L.} and Javed Khan and Shern, {Jack F.} and Joshua Schiffman and Lisa Mirabello and Savage, {Sharon A.} and Marc Ladanyi and Paul Meltzer and Bult, {Carol J.} and Adamson, {Peter C.} and Lupo, {Philip J.} and Rajen Mody and DuBois, {Steven G.} and Parsons, {D. Williams} and Chand Khanna and Ching Lau and Hawkins, {Douglas S.} and Randall, {R. Lor} and Malcolm Smith and Sorensen, {Poul H.} and Plon, {Sharon E.} and Skapek, {Stephen X.} and Stephen Lessnick and Richard Gorlick and Reed, {Damon R.}",
year = "2016",
month = "5",
day = "1",
doi = "10.1016/j.cancergen.2016.03.004",
language = "English (US)",
volume = "209",
pages = "182--194",
journal = "Cancer genetics",
issn = "2210-7762",
publisher = "Elsevier BV",
number = "5",

}

TY - JOUR

T1 - Current state of pediatric sarcoma biology and opportunities for future discovery

T2 - A report from the sarcoma translational research workshop

AU - Hingorani, Pooja

AU - Janeway, Katherine

AU - Crompton, Brian D.

AU - Kadoch, Cigall

AU - Mackall, Crystal L.

AU - Khan, Javed

AU - Shern, Jack F.

AU - Schiffman, Joshua

AU - Mirabello, Lisa

AU - Savage, Sharon A.

AU - Ladanyi, Marc

AU - Meltzer, Paul

AU - Bult, Carol J.

AU - Adamson, Peter C.

AU - Lupo, Philip J.

AU - Mody, Rajen

AU - DuBois, Steven G.

AU - Parsons, D. Williams

AU - Khanna, Chand

AU - Lau, Ching

AU - Hawkins, Douglas S.

AU - Randall, R. Lor

AU - Smith, Malcolm

AU - Sorensen, Poul H.

AU - Plon, Sharon E.

AU - Skapek, Stephen X.

AU - Lessnick, Stephen

AU - Gorlick, Richard

AU - Reed, Damon R.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time. However, much remains to be accomplished in this arena especially with regard to translating all of this new knowledge to the bedside. To this end, a meeting was convened in Philadelphia, PA, on April 18, 2015 sponsored by the QuadW foundation, Children's Oncology Group and CureSearch for Children's Cancer that brought together sarcoma clinicians and scientists from North America to review the current state of pediatric sarcoma biology and ongoing/planned genomics based clinical trials in an effort to identify and bridge knowledge gaps that continue to exist at present. At the conclusion of the workshop, three key objectives that would significantly further our understanding of sarcoma were identified and a proposal was put forward to develop an all-encompassing pediatric sarcoma biology protocol that would address these specific needs. This review summarizes the proceedings of the workshop.

AB - Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time. However, much remains to be accomplished in this arena especially with regard to translating all of this new knowledge to the bedside. To this end, a meeting was convened in Philadelphia, PA, on April 18, 2015 sponsored by the QuadW foundation, Children's Oncology Group and CureSearch for Children's Cancer that brought together sarcoma clinicians and scientists from North America to review the current state of pediatric sarcoma biology and ongoing/planned genomics based clinical trials in an effort to identify and bridge knowledge gaps that continue to exist at present. At the conclusion of the workshop, three key objectives that would significantly further our understanding of sarcoma were identified and a proposal was put forward to develop an all-encompassing pediatric sarcoma biology protocol that would address these specific needs. This review summarizes the proceedings of the workshop.

KW - Genomics

KW - Molecular profiling

KW - Patient derived xenografts

KW - Pediatric sarcoma

KW - Precision medicine

KW - Sarcoma biology

UR - http://www.scopus.com/inward/record.url?scp=84964238223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964238223&partnerID=8YFLogxK

U2 - 10.1016/j.cancergen.2016.03.004

DO - 10.1016/j.cancergen.2016.03.004

M3 - Review article

VL - 209

SP - 182

EP - 194

JO - Cancer genetics

JF - Cancer genetics

SN - 2210-7762

IS - 5

ER -