Cumulative Effects of Stressful Childhood Experiences on Delusions and Hallucinations

Kristina H. Muenzenmaier, Azizi A. Seixas, Andres R. Schneeberger, Dorothy M. Castille, Joseph Battaglia, Bruce G. Link

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The association between stressful childhood experiences (SCE) and psychotic symptoms is still not clearly understood, and different causal pathways have been proposed. Generalized estimating equation modeling was used to test the dose–response relationship between SCE and delusions and hallucinations at baseline and follow-up periods and the possible confounding effects of dissociation on this relationship. The prevalence of SCE in individuals with psychotic disorders was high, with more co-occurring SCE categories being positively associated with more types of delusions and hallucinations. Each additional SCE was associated with a 1.20 increase in the incidence rate ratio (95% confidence interval [CI; 1.09, 1.32]) for hallucinations and a 1.19 increase (CI [1.09, 1.29]) for delusions, supporting a dose–response association. After we controlled for the mediating effects of dissociative symptoms at follow-up, SCE remained independently associated with delusions. We propose that cumulative SCE can result in complex trauma reactions that present with a broad range of symptomatology, including dissociative, posttraumatic stress disorder, and psychotic symptoms.

Original languageEnglish (US)
Pages (from-to)442-462
Number of pages21
JournalJournal of Trauma and Dissociation
Volume16
Issue number4
DOIs
StatePublished - Aug 8 2015

Fingerprint

Delusions
Hallucinations
Dissociative Disorders
Post-Traumatic Stress Disorders
Psychotic Disorders
Confidence Intervals
Incidence
Wounds and Injuries

Keywords

  • dissociation
  • psychosis
  • schizophrenia
  • severe mental illness
  • trauma

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Cumulative Effects of Stressful Childhood Experiences on Delusions and Hallucinations. / Muenzenmaier, Kristina H.; Seixas, Azizi A.; Schneeberger, Andres R.; Castille, Dorothy M.; Battaglia, Joseph; Link, Bruce G.

In: Journal of Trauma and Dissociation, Vol. 16, No. 4, 08.08.2015, p. 442-462.

Research output: Contribution to journalArticle

Muenzenmaier, Kristina H. ; Seixas, Azizi A. ; Schneeberger, Andres R. ; Castille, Dorothy M. ; Battaglia, Joseph ; Link, Bruce G. / Cumulative Effects of Stressful Childhood Experiences on Delusions and Hallucinations. In: Journal of Trauma and Dissociation. 2015 ; Vol. 16, No. 4. pp. 442-462.
@article{fcffe45f00a74cf3bec6e68b67eb3bae,
title = "Cumulative Effects of Stressful Childhood Experiences on Delusions and Hallucinations",
abstract = "The association between stressful childhood experiences (SCE) and psychotic symptoms is still not clearly understood, and different causal pathways have been proposed. Generalized estimating equation modeling was used to test the dose–response relationship between SCE and delusions and hallucinations at baseline and follow-up periods and the possible confounding effects of dissociation on this relationship. The prevalence of SCE in individuals with psychotic disorders was high, with more co-occurring SCE categories being positively associated with more types of delusions and hallucinations. Each additional SCE was associated with a 1.20 increase in the incidence rate ratio (95{\%} confidence interval [CI; 1.09, 1.32]) for hallucinations and a 1.19 increase (CI [1.09, 1.29]) for delusions, supporting a dose–response association. After we controlled for the mediating effects of dissociative symptoms at follow-up, SCE remained independently associated with delusions. We propose that cumulative SCE can result in complex trauma reactions that present with a broad range of symptomatology, including dissociative, posttraumatic stress disorder, and psychotic symptoms.",
keywords = "dissociation, psychosis, schizophrenia, severe mental illness, trauma",
author = "Muenzenmaier, {Kristina H.} and Seixas, {Azizi A.} and Schneeberger, {Andres R.} and Castille, {Dorothy M.} and Joseph Battaglia and Link, {Bruce G.}",
year = "2015",
month = "8",
day = "8",
doi = "10.1080/15299732.2015.1018475",
language = "English (US)",
volume = "16",
pages = "442--462",
journal = "Journal of Trauma and Dissociation",
issn = "1529-9732",
publisher = "Routledge",
number = "4",

}

TY - JOUR

T1 - Cumulative Effects of Stressful Childhood Experiences on Delusions and Hallucinations

AU - Muenzenmaier, Kristina H.

AU - Seixas, Azizi A.

AU - Schneeberger, Andres R.

AU - Castille, Dorothy M.

AU - Battaglia, Joseph

AU - Link, Bruce G.

PY - 2015/8/8

Y1 - 2015/8/8

N2 - The association between stressful childhood experiences (SCE) and psychotic symptoms is still not clearly understood, and different causal pathways have been proposed. Generalized estimating equation modeling was used to test the dose–response relationship between SCE and delusions and hallucinations at baseline and follow-up periods and the possible confounding effects of dissociation on this relationship. The prevalence of SCE in individuals with psychotic disorders was high, with more co-occurring SCE categories being positively associated with more types of delusions and hallucinations. Each additional SCE was associated with a 1.20 increase in the incidence rate ratio (95% confidence interval [CI; 1.09, 1.32]) for hallucinations and a 1.19 increase (CI [1.09, 1.29]) for delusions, supporting a dose–response association. After we controlled for the mediating effects of dissociative symptoms at follow-up, SCE remained independently associated with delusions. We propose that cumulative SCE can result in complex trauma reactions that present with a broad range of symptomatology, including dissociative, posttraumatic stress disorder, and psychotic symptoms.

AB - The association between stressful childhood experiences (SCE) and psychotic symptoms is still not clearly understood, and different causal pathways have been proposed. Generalized estimating equation modeling was used to test the dose–response relationship between SCE and delusions and hallucinations at baseline and follow-up periods and the possible confounding effects of dissociation on this relationship. The prevalence of SCE in individuals with psychotic disorders was high, with more co-occurring SCE categories being positively associated with more types of delusions and hallucinations. Each additional SCE was associated with a 1.20 increase in the incidence rate ratio (95% confidence interval [CI; 1.09, 1.32]) for hallucinations and a 1.19 increase (CI [1.09, 1.29]) for delusions, supporting a dose–response association. After we controlled for the mediating effects of dissociative symptoms at follow-up, SCE remained independently associated with delusions. We propose that cumulative SCE can result in complex trauma reactions that present with a broad range of symptomatology, including dissociative, posttraumatic stress disorder, and psychotic symptoms.

KW - dissociation

KW - psychosis

KW - schizophrenia

KW - severe mental illness

KW - trauma

UR - http://www.scopus.com/inward/record.url?scp=84938487967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938487967&partnerID=8YFLogxK

U2 - 10.1080/15299732.2015.1018475

DO - 10.1080/15299732.2015.1018475

M3 - Article

VL - 16

SP - 442

EP - 462

JO - Journal of Trauma and Dissociation

JF - Journal of Trauma and Dissociation

SN - 1529-9732

IS - 4

ER -