Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes

Yan Zheng, Yanping Li, Qibin Qi, Adela Hruby, Jo Ann E. Manson, Walter C. Willett, Brian M. Wolpin, Frank B. Hu, Lu Qi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D. Methods: We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010). Results: We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01). Conclusions: Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.

Original languageEnglish (US)
Pages (from-to)1482-1492
Number of pages11
JournalInternational Journal of Epidemiology
Volume45
Issue number5
DOIs
StatePublished - Jan 1 2016

Fingerprint

Branched Chain Amino Acids
Type 2 Diabetes Mellitus
Incidence
Isoleucine
Valine
Leucine
Health
Meta-Analysis
Nurses
Demography
Confidence Intervals
Amino Acids

Keywords

  • Branched-chain amino acids
  • Cohort study
  • Diet
  • Type 2 diabetes

ASJC Scopus subject areas

  • Epidemiology

Cite this

Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes. / Zheng, Yan; Li, Yanping; Qi, Qibin; Hruby, Adela; Manson, Jo Ann E.; Willett, Walter C.; Wolpin, Brian M.; Hu, Frank B.; Qi, Lu.

In: International Journal of Epidemiology, Vol. 45, No. 5, 01.01.2016, p. 1482-1492.

Research output: Contribution to journalArticle

Zheng, Y, Li, Y, Qi, Q, Hruby, A, Manson, JAE, Willett, WC, Wolpin, BM, Hu, FB & Qi, L 2016, 'Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes', International Journal of Epidemiology, vol. 45, no. 5, pp. 1482-1492. https://doi.org/10.1093/ije/dyw143
Zheng, Yan ; Li, Yanping ; Qi, Qibin ; Hruby, Adela ; Manson, Jo Ann E. ; Willett, Walter C. ; Wolpin, Brian M. ; Hu, Frank B. ; Qi, Lu. / Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes. In: International Journal of Epidemiology. 2016 ; Vol. 45, No. 5. pp. 1482-1492.
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AU - Li, Yanping

AU - Qi, Qibin

AU - Hruby, Adela

AU - Manson, Jo Ann E.

AU - Willett, Walter C.

AU - Wolpin, Brian M.

AU - Hu, Frank B.

AU - Qi, Lu

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N2 - Background: Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D. Methods: We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010). Results: We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01). Conclusions: Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.

AB - Background: Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D. Methods: We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010). Results: We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01). Conclusions: Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.

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