Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer: A systematic review

Primož Strojan, Jan B. Vermorken, Jonathan J. Beitler, Nabil F. Saba, Missak Haigentz, Paolo Bossi, Francis P. Worden, Johannes A. Langendijk, Avraham Eisbruch, William M. Mendenhall, Anne W.M. Lee, Louis B. Harrison, Carol R. Bradford, Robert Smee, Carl E. Silver, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalReview article

68 Scopus citations

Abstract

Background The optimal cumulative dose and timing of cisplatin administration in various concurrent chemoradiotherapy protocols for nonmetastatic head and neck squamous cell carcinoma (HNSCC) has not been determined. Methods The absolute survival benefit at 5 years of concurrent chemoradiotherapy protocols versus radiotherapy alone observed in prospective randomized trials reporting on the use of cisplatin monochemotherapy for nonnasopharyngeal HNSCC was extracted. In the case of nonrandomized studies, the outcome results at 2 years were compared between groups of patients receiving different cumulative cisplatin doses. Results Eleven randomized trials and 7 nonrandomized studies were identified. In 6 definitive radiotherapy phase III trials, a statistically significant association (p =.027) between cumulative cisplatin dose, independent of the schedule, and overall survival benefit was observed for higher doses. Conclusion Results support the conclusion that the cumulative dose of cisplatin in concurrent chemoradiation protocols for HNSCC has a significant positive correlation with survival.

Original languageEnglish (US)
Pages (from-to)E2151-E2158
JournalHead and Neck
Volume38
DOIs
StatePublished - Apr 1 2016

Keywords

  • cisplatin
  • concurrent chemoradiotherapy
  • cumulative dose
  • outcome
  • radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Strojan, P., Vermorken, J. B., Beitler, J. J., Saba, N. F., Haigentz, M., Bossi, P., Worden, F. P., Langendijk, J. A., Eisbruch, A., Mendenhall, W. M., Lee, A. W. M., Harrison, L. B., Bradford, C. R., Smee, R., Silver, C. E., Rinaldo, A., & Ferlito, A. (2016). Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer: A systematic review. Head and Neck, 38, E2151-E2158. https://doi.org/10.1002/hed.24026