Cu Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

Noriyuki Shibata, Asao Hirano, Makio Kobayashi, Shoichi Sasaki, Kato Takeo, Sadayuki Matsumoto, Zenji Shiozawa, Takashi Komori, Akito Ikemoto, Takahiko Umahara, Kohtaro Asayama

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Abstract

Cu Zn superoxide dismutase (SOD)-like immunoreactivity (LI) was found within Lewy body-like inclusions (LBIs) in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (ALS) by using an antibody to human Cu ZnSOD. LBIs were detected in the anterior horn cells in 10 of 20 patients with sporadic ALS. In each of these patients, 7 to 60% of LBIs showed Cu ZnSOD-LI. No Cu ZnSOD-LI was detected in intact neurons and glia in the 20 ALS patients, as well as in these cells in 10 normal control individuals. The skein-like inclusions and Bunina bodies, which were found in all of the 20 ALS cases, showed no Cu ZnSOD-LI. Thus, Cu ZnSOD appears to play roles in the production and/or degradation process of LBIs.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalNeuroscience Letters
Volume179
Issue number1-2
DOIs
StatePublished - Sep 26 1994

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Keywords

  • Amyotrophic lateral sclerosis
  • Bunina body
  • Immunohistochemistry
  • Lewy body-like inclusion
  • Skein-like inclusion
  • Superoxide dismutase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Shibata, N., Hirano, A., Kobayashi, M., Sasaki, S., Takeo, K., Matsumoto, S., Shiozawa, Z., Komori, T., Ikemoto, A., Umahara, T., & Asayama, K. (1994). Cu Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis. Neuroscience Letters, 179(1-2), 149-152. https://doi.org/10.1016/0304-3940(94)90956-3