TY - JOUR
T1 - CSF-1 regulation of the wandering macrophage
T2 - Complexity in action
AU - Pixley, Fiona J.
AU - Stanley, E. Richard
N1 - Funding Information:
We thank Yee-Guide Yeung and Paul Jubinsky for their comments. This work was supported by National Institutes of Health grants to F.J.P. (KO8 CA097348) and E.R.S. (RO1 CA32551, RO1 CA 25604 and PO1 CA100324), and by the Albert Einstein Cancer Center (P30 CA13330).
PY - 2004/11
Y1 - 2004/11
N2 - Most tissue macrophages and osteoclasts are regulated by colony-stimulating factor-1 (CSF-1, also known as macrophage CSF). The effects of CSF-1 are mediated by the CSF-1 receptor tyrosine kinase (CSF-1R), through autophosphorylation of CSF-1R and the subsequent phosphorylation of downstream molecules. Triggering this phosphorylation cascade increases gene transcription and protein translation, and induces cytoskeletal remodeling by several signaling pathways, leading to the survival, proliferation and differentiation of target cells. CSF-1-regulated tissue macrophages are important for innate immunity and for tissue development and function. Because CSF-1 regulates the survival, proliferation and chemotaxis of macrophages and supports their activation, this factor is involved in the pathogenesis of several diseases.
AB - Most tissue macrophages and osteoclasts are regulated by colony-stimulating factor-1 (CSF-1, also known as macrophage CSF). The effects of CSF-1 are mediated by the CSF-1 receptor tyrosine kinase (CSF-1R), through autophosphorylation of CSF-1R and the subsequent phosphorylation of downstream molecules. Triggering this phosphorylation cascade increases gene transcription and protein translation, and induces cytoskeletal remodeling by several signaling pathways, leading to the survival, proliferation and differentiation of target cells. CSF-1-regulated tissue macrophages are important for innate immunity and for tissue development and function. Because CSF-1 regulates the survival, proliferation and chemotaxis of macrophages and supports their activation, this factor is involved in the pathogenesis of several diseases.
UR - http://www.scopus.com/inward/record.url?scp=7444254061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7444254061&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2004.09.016
DO - 10.1016/j.tcb.2004.09.016
M3 - Review article
C2 - 15519852
AN - SCOPUS:7444254061
SN - 0962-8924
VL - 14
SP - 628
EP - 638
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 11
ER -