Crystalluria

A clinically useful investigation in children with primary hyperoxaluria post-transplantation

Philippe Jouvet, Laurence Priqueler, Marie France Gagnadoux, Dominique M. Jan, Annick Beringer, Florence Lacaille, Yan Revillon, Michel Broyer, Michel Daudon

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Primary hyperoxaluria type I (PH 1) is a congenital error of metabolism that can be manifested by an increased oxalate production, and ultimately result in kidney failure. After a combined liver/kidney transplantation, children with PHI have persistant excretion of oxalate that causes crystal formation in the urinary tract, and could result in systemic oxalosis and eventual graft failure. We speculated that crystalluria may be predictive of this nephrolithogenic tendency and thus investigated the effect of an intensive therapeutic strategy to prevent crystal formation in 13 children at our hospital. Oxalate crystal volume (OCV) measurements were performed at regular intervals for 36 months, and compared with urine supersaturation measurements. We found that crystalluria with the OCV measurement is non- invasive, easily performed, and gives feedback on the efficacy of PH I therapy within one hour. Further study is needed to determine whether this method is a better predictor of nephrocalcinosis than is supersaturation alone.

Original languageEnglish (US)
Pages (from-to)1412-1416
Number of pages5
JournalKidney International
Volume53
Issue number5
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Primary Hyperoxaluria
Oxalates
Transplantation
Hyperoxaluria
Nephrocalcinosis
Therapeutic Uses
Urinary Tract
Liver Transplantation
Kidney Transplantation
Renal Insufficiency
Urine
Transplants

Keywords

  • Children
  • Crystalluria
  • Nephrocalcinosis
  • Oxalosis
  • Transplantation
  • Urine supersaturation

ASJC Scopus subject areas

  • Nephrology

Cite this

Crystalluria : A clinically useful investigation in children with primary hyperoxaluria post-transplantation. / Jouvet, Philippe; Priqueler, Laurence; Gagnadoux, Marie France; Jan, Dominique M.; Beringer, Annick; Lacaille, Florence; Revillon, Yan; Broyer, Michel; Daudon, Michel.

In: Kidney International, Vol. 53, No. 5, 1998, p. 1412-1416.

Research output: Contribution to journalArticle

Jouvet, P, Priqueler, L, Gagnadoux, MF, Jan, DM, Beringer, A, Lacaille, F, Revillon, Y, Broyer, M & Daudon, M 1998, 'Crystalluria: A clinically useful investigation in children with primary hyperoxaluria post-transplantation', Kidney International, vol. 53, no. 5, pp. 1412-1416. https://doi.org/10.1046/j.1523-1755.1998.00876.x
Jouvet, Philippe ; Priqueler, Laurence ; Gagnadoux, Marie France ; Jan, Dominique M. ; Beringer, Annick ; Lacaille, Florence ; Revillon, Yan ; Broyer, Michel ; Daudon, Michel. / Crystalluria : A clinically useful investigation in children with primary hyperoxaluria post-transplantation. In: Kidney International. 1998 ; Vol. 53, No. 5. pp. 1412-1416.
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