CTLA-4 is a dimeric T-cell surface receptor responsible for transducing signals that down-regulate activated T cells upon binding B7 ligands. The disulfide-linked homodimer of the extracellular segment of human CTLA-4 and the receptor-binding domain of human B7-2 were purified and cocrystallized. Diffraction from these crystals is consistent with the monoclinic space group P21 (unit-cell parameters a = 47.85, b = 54.56, c = 103.09 Å, β = 91.63); native data have been collected to 3.2 Å resolution.
|Original language||English (US)|
|Number of pages||2|
|Journal||Acta Crystallographica Section D: Biological Crystallography|
|Publication status||Published - Jul 4 2001|
ASJC Scopus subject areas
- Structural Biology