Cryptogenic stroke

how to define it? How to treat it?

Ava L. Liberman, Shyam Prabhakaran

Research output: Contribution to journalReview article

Abstract

Stroke is a leading cause of disability worldwide. Cryptogenic strokes (CS) account for almost a quarter of ischemic strokes despite modern diagnostic evaluation. A working definition of CS based on stroke classification systems is essential for accurate conceptualization of this common entity. Mechanistic categories (potential paradoxical embolism; atherosclerotic disease of the aorta or supra-aortic vasculature; and occult arrhythmia) should aide in parsing the often heterogeneous mix of conditions included in the CS subtype. Despite efforts to unravel mechanisms of CS, specific or targeted recurrent stroke prevention strategies are lacking. For example, recent trials have shown no clear benefit of patent foramen ovale closure in stroke prevention after CS. There are promising ongoing clinical trials that will address appropriate diagnostic evaluations in CS as well as novel therapeutic interventions. Overall, a standardized approach must be framed to diagnose and manage patients with CS and guide clinical practice and future research.

Original languageEnglish (US)
Pages (from-to)423
Number of pages1
JournalCurrent Cardiology Reports
Volume15
Issue number12
StatePublished - Dec 2013
Externally publishedYes

Fingerprint

Stroke
Paradoxical Embolism
Patent Foramen Ovale
Aorta
Cardiac Arrhythmias
Clinical Trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cryptogenic stroke : how to define it? How to treat it? / Liberman, Ava L.; Prabhakaran, Shyam.

In: Current Cardiology Reports, Vol. 15, No. 12, 12.2013, p. 423.

Research output: Contribution to journalReview article

Liberman, Ava L. ; Prabhakaran, Shyam. / Cryptogenic stroke : how to define it? How to treat it?. In: Current Cardiology Reports. 2013 ; Vol. 15, No. 12. pp. 423.
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