Cryptococcosis in children with AIDS

Jacobo Abadi, Sharon Nachman, Amy B. Kressel, Liise-anne Pirofski

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/μL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred in children vertically infected with HIV and in children between 6 and 12 years of age. The clinical and laboratory characteristics of this pediatric cohort were similar to those of adults with AIDS and cryptococcosis. On the basis of a subset of the cases, a 10-year point prevalence of cryptococcosis among children with AIDS of ~1% was estimated.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalClinical Infectious Diseases
Volume28
Issue number2
StatePublished - 1999

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Cryptococcosis
Acquired Immunodeficiency Syndrome
Cryptococcus neoformans
HIV
CD4 Lymphocyte Count
Cerebrospinal Fluid
Pediatrics
Antigens
Infection
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Abadi, J., Nachman, S., Kressel, A. B., & Pirofski, L. (1999). Cryptococcosis in children with AIDS. Clinical Infectious Diseases, 28(2), 309-313.

Cryptococcosis in children with AIDS. / Abadi, Jacobo; Nachman, Sharon; Kressel, Amy B.; Pirofski, Liise-anne.

In: Clinical Infectious Diseases, Vol. 28, No. 2, 1999, p. 309-313.

Research output: Contribution to journalArticle

Abadi, J, Nachman, S, Kressel, AB & Pirofski, L 1999, 'Cryptococcosis in children with AIDS', Clinical Infectious Diseases, vol. 28, no. 2, pp. 309-313.
Abadi J, Nachman S, Kressel AB, Pirofski L. Cryptococcosis in children with AIDS. Clinical Infectious Diseases. 1999;28(2):309-313.
Abadi, Jacobo ; Nachman, Sharon ; Kressel, Amy B. ; Pirofski, Liise-anne. / Cryptococcosis in children with AIDS. In: Clinical Infectious Diseases. 1999 ; Vol. 28, No. 2. pp. 309-313.
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