Cryptococcosis in children with AIDS

Jacobo Abadi; Sharon Nachman; Amy B. Kressel; Liise Anne Pirofski

doi:10.1086/515130

Cryptococcosis in children with AIDS

Jacobo Abadi, Sharon Nachman, Amy B. Kressel, Liise Anne Pirofski

Medicine

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4⁺ cell count of 54/μL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred in children vertically infected with HIV and in children between 6 and 12 years of age. The clinical and laboratory characteristics of this pediatric cohort were similar to those of adults with AIDS and cryptococcosis. On the basis of a subset of the cases, a 10-year point prevalence of cryptococcosis among children with AIDS of ~1% was estimated.

Original language	English (US)
Pages (from-to)	309-313
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	28
Issue number	2
DOIs	https://doi.org/10.1086/515130
State	Published - 1999

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/515130

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title = "Cryptococcosis in children with AIDS",

abstract = "We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/μL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred in children vertically infected with HIV and in children between 6 and 12 years of age. The clinical and laboratory characteristics of this pediatric cohort were similar to those of adults with AIDS and cryptococcosis. On the basis of a subset of the cases, a 10-year point prevalence of cryptococcosis among children with AIDS of ~1% was estimated.",

author = "Jacobo Abadi and Sharon Nachman and Kressel, {Amy B.} and Pirofski, {Liise Anne}",

note = "Funding Information: Financial support: This work was supported by the National Institute of Allergy and Infectious Diseases (RO1 35370). L.P. was supported by a Howard Hughes Medical Institute Research Resources Program for Medical Schools Pilot Research Project Award, and J.A. was supported by an NCI Immunology and Immuno-Oncology Training Grant (5-T32 CA 09173).",

year = "1999",

doi = "10.1086/515130",

language = "English (US)",

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pages = "309--313",

journal = "Clinical Infectious Diseases",

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T1 - Cryptococcosis in children with AIDS

AU - Abadi, Jacobo

AU - Nachman, Sharon

AU - Kressel, Amy B.

AU - Pirofski, Liise Anne

N1 - Funding Information: Financial support: This work was supported by the National Institute of Allergy and Infectious Diseases (RO1 35370). L.P. was supported by a Howard Hughes Medical Institute Research Resources Program for Medical Schools Pilot Research Project Award, and J.A. was supported by an NCI Immunology and Immuno-Oncology Training Grant (5-T32 CA 09173).

PY - 1999

Y1 - 1999

N2 - We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/μL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred in children vertically infected with HIV and in children between 6 and 12 years of age. The clinical and laboratory characteristics of this pediatric cohort were similar to those of adults with AIDS and cryptococcosis. On the basis of a subset of the cases, a 10-year point prevalence of cryptococcosis among children with AIDS of ~1% was estimated.

AB - We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/μL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred in children vertically infected with HIV and in children between 6 and 12 years of age. The clinical and laboratory characteristics of this pediatric cohort were similar to those of adults with AIDS and cryptococcosis. On the basis of a subset of the cases, a 10-year point prevalence of cryptococcosis among children with AIDS of ~1% was estimated.

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JF - Clinical Infectious Diseases

IS - 2

ER -

Cryptococcosis in children with AIDS

Abstract

ASJC Scopus subject areas

UN SDGs

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