TY - JOUR
T1 - Cross talk between neutrophils and the microbiota
AU - Zhang, Dachuan
AU - Frenette, Paul S.
N1 - Publisher Copyright:
© 2019 by The American Society of Hematology
PY - 2019/5/16
Y1 - 2019/5/16
N2 - The microbiota has emerged as an important regulator of the host immunity by the induction, functional modulation, or suppression of local and systemic immune responses. In return, the host immune system restricts translocation and fine tunes the composition and distribution of the microbiota to maintain a beneficial symbiosis. This paradigm applies to neutrophils, a critical component of the innate immunity, allowing their production and function to be influenced by microbial components and metabolites derived from the microbiota, and engaging them in the process of microbiota containment and regulation. The cross talk between neutrophils and the microbiota adjusts the magnitude of neutrophil-mediated inflammation on challenge while preventing neutrophil responses against commensals under steady state. Here, we review the major molecular and cellular mediators of the interactions between neutrophils and the microbiota and discuss their interplay and contribution in chronic inflammatory diseases and cancer.
AB - The microbiota has emerged as an important regulator of the host immunity by the induction, functional modulation, or suppression of local and systemic immune responses. In return, the host immune system restricts translocation and fine tunes the composition and distribution of the microbiota to maintain a beneficial symbiosis. This paradigm applies to neutrophils, a critical component of the innate immunity, allowing their production and function to be influenced by microbial components and metabolites derived from the microbiota, and engaging them in the process of microbiota containment and regulation. The cross talk between neutrophils and the microbiota adjusts the magnitude of neutrophil-mediated inflammation on challenge while preventing neutrophil responses against commensals under steady state. Here, we review the major molecular and cellular mediators of the interactions between neutrophils and the microbiota and discuss their interplay and contribution in chronic inflammatory diseases and cancer.
UR - http://www.scopus.com/inward/record.url?scp=85066918130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066918130&partnerID=8YFLogxK
U2 - 10.1182/blood-2018-11-844555
DO - 10.1182/blood-2018-11-844555
M3 - Review article
C2 - 30898860
AN - SCOPUS:85066918130
SN - 0006-4971
VL - 133
SP - 2168
EP - 2177
JO - Blood
JF - Blood
IS - 20
ER -