TY - JOUR
T1 - Cross-Species Induction and Enhancement of Antimicrobial Properties in Response to Gamma Irradiation in Exiguobacterium sp. HKG 126
AU - Pathak, Rajiv
AU - Kumar, Raj
AU - Gautam, Hemant K.
N1 - Funding Information:
Acknowledgments The authors are grateful to Dr. Rajesh Gokhle, director of CSIR-IGIB for providing infrastructural facilities and financial assistance (HKG 61). R. Pathak would also like to acknowledge University Grants Commission (UGC), India, for providing Senior Research Fellowship.
PY - 2013/6
Y1 - 2013/6
N2 - A gram positive, extreme haloalkaliphilic, radioresistant bacterium was isolated from mangrove region of Kerala (India) which was characterized as Exiguobacterium sp. HKG-126 using morphological, physiological, biochemical and molecular characterization. Present investigation was undertaken to examine Exiguobacterium sp. as a potential source of broad-spectrum antimicrobial activity and enhancement in this activity was observed due to cross-species/cross-genera induction and also in response to high dose of gamma (γ) irradiation. Individual studies on the antimicrobial activity of all the co-cultivated bacterial strains before and after mixed culture fermentation, showed excellent enhancement in antimicrobial activity of Exiguobacterium sp. against a variety of clinical pathogens. To the best of our knowledge, this is the first report showing existence of an extremely high radioresistant strain of (up to 15 kGy) Exiguobacterium sp.
AB - A gram positive, extreme haloalkaliphilic, radioresistant bacterium was isolated from mangrove region of Kerala (India) which was characterized as Exiguobacterium sp. HKG-126 using morphological, physiological, biochemical and molecular characterization. Present investigation was undertaken to examine Exiguobacterium sp. as a potential source of broad-spectrum antimicrobial activity and enhancement in this activity was observed due to cross-species/cross-genera induction and also in response to high dose of gamma (γ) irradiation. Individual studies on the antimicrobial activity of all the co-cultivated bacterial strains before and after mixed culture fermentation, showed excellent enhancement in antimicrobial activity of Exiguobacterium sp. against a variety of clinical pathogens. To the best of our knowledge, this is the first report showing existence of an extremely high radioresistant strain of (up to 15 kGy) Exiguobacterium sp.
KW - Antimicrobial activity
KW - Cross-species induction
KW - Exiguobacterium sp.
KW - Extraction of secondary metabolites
KW - Gamma irradiation
UR - http://www.scopus.com/inward/record.url?scp=84876187618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876187618&partnerID=8YFLogxK
U2 - 10.1007/s12088-013-0369-0
DO - 10.1007/s12088-013-0369-0
M3 - Article
AN - SCOPUS:84876187618
SN - 0046-8991
VL - 53
SP - 130
EP - 136
JO - Indian Journal of Microbiology
JF - Indian Journal of Microbiology
IS - 2
ER -