Crescentic post-streptococcal glomerulonephritis with nephrotic syndrome in the adult

Is aggressive therapy warranted?

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The prognosis for adults with acute post-streptococcal glomerulonephritis (PSGN) who present with crescentic glomerulonephritis and nephrotic proteinuria is not known. We report a patient with rapidly progressive glomerulonephritis and nephrotic-range proteinuria following acute pharyngitis, in whom serologic and kidney biopsy findings led to a diagnosis of PSGN. The patient was treated with corticosteroids and anti-hypertensive medications resulting in improvement in renal function and decrease in proteinuria. These results suggest that aggressive treatment of crescentic PSGN with nephrotic syndrome can result in a favorable outcome.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalClinical Nephrology
Volume63
Issue number5
StatePublished - May 2005

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Nephrotic Syndrome
Glomerulonephritis
Proteinuria
Kidney
Therapeutics
Pharyngitis
Antihypertensive Agents
Adrenal Cortex Hormones
Biopsy

Keywords

  • Corticosteroids
  • Nephrotic syndrome
  • Post-streptococcal glomerulonephritis

ASJC Scopus subject areas

  • Nephrology

Cite this

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title = "Crescentic post-streptococcal glomerulonephritis with nephrotic syndrome in the adult: Is aggressive therapy warranted?",
abstract = "The prognosis for adults with acute post-streptococcal glomerulonephritis (PSGN) who present with crescentic glomerulonephritis and nephrotic proteinuria is not known. We report a patient with rapidly progressive glomerulonephritis and nephrotic-range proteinuria following acute pharyngitis, in whom serologic and kidney biopsy findings led to a diagnosis of PSGN. The patient was treated with corticosteroids and anti-hypertensive medications resulting in improvement in renal function and decrease in proteinuria. These results suggest that aggressive treatment of crescentic PSGN with nephrotic syndrome can result in a favorable outcome.",
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AU - Raff, Amanda C.

AU - Hebert, Tiffany M.

AU - Pullman, James M.

AU - Coco, Maria

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N2 - The prognosis for adults with acute post-streptococcal glomerulonephritis (PSGN) who present with crescentic glomerulonephritis and nephrotic proteinuria is not known. We report a patient with rapidly progressive glomerulonephritis and nephrotic-range proteinuria following acute pharyngitis, in whom serologic and kidney biopsy findings led to a diagnosis of PSGN. The patient was treated with corticosteroids and anti-hypertensive medications resulting in improvement in renal function and decrease in proteinuria. These results suggest that aggressive treatment of crescentic PSGN with nephrotic syndrome can result in a favorable outcome.

AB - The prognosis for adults with acute post-streptococcal glomerulonephritis (PSGN) who present with crescentic glomerulonephritis and nephrotic proteinuria is not known. We report a patient with rapidly progressive glomerulonephritis and nephrotic-range proteinuria following acute pharyngitis, in whom serologic and kidney biopsy findings led to a diagnosis of PSGN. The patient was treated with corticosteroids and anti-hypertensive medications resulting in improvement in renal function and decrease in proteinuria. These results suggest that aggressive treatment of crescentic PSGN with nephrotic syndrome can result in a favorable outcome.

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