Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders

Kristen J. Brennand, M. Carol Marchetto, Nissim Benvenisty, Oliver Brüstle, Allison Ebert, Juan Carlos Izpisua Belmonte, Ajamete Kaykas, Madeline A. Lancaster, Frederick J. Livesey, Michael J. McConnell, Ronald D. McKay, Eric M. Morrow, Alysson R. Muotri, David M. Panchision, Lee L. Rubin, Akira Sawa, Frank Soldner, Hongjun Song, Lorenz Studer, Sally TempleFlora M. Vaccarino, Jun Wu, Pierre Vanderhaeghen, Fred H. Gage, Rudolf Jaenisch

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

Original languageEnglish (US)
Pages (from-to)933-945
Number of pages13
JournalStem Cell Reports
Volume5
Issue number6
DOIs
StatePublished - Dec 8 2015
Externally publishedYes

Fingerprint

Induced Pluripotent Stem Cells
Brain Diseases
Brain
Drug Discovery
In Vitro Techniques
Optimism

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Brennand, K. J., Marchetto, M. C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J. C., ... Jaenisch, R. (2015). Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders. Stem Cell Reports, 5(6), 933-945. https://doi.org/10.1016/j.stemcr.2015.10.011

Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders. / Brennand, Kristen J.; Marchetto, M. Carol; Benvenisty, Nissim; Brüstle, Oliver; Ebert, Allison; Izpisua Belmonte, Juan Carlos; Kaykas, Ajamete; Lancaster, Madeline A.; Livesey, Frederick J.; McConnell, Michael J.; McKay, Ronald D.; Morrow, Eric M.; Muotri, Alysson R.; Panchision, David M.; Rubin, Lee L.; Sawa, Akira; Soldner, Frank; Song, Hongjun; Studer, Lorenz; Temple, Sally; Vaccarino, Flora M.; Wu, Jun; Vanderhaeghen, Pierre; Gage, Fred H.; Jaenisch, Rudolf.

In: Stem Cell Reports, Vol. 5, No. 6, 08.12.2015, p. 933-945.

Research output: Contribution to journalArticle

Brennand, KJ, Marchetto, MC, Benvenisty, N, Brüstle, O, Ebert, A, Izpisua Belmonte, JC, Kaykas, A, Lancaster, MA, Livesey, FJ, McConnell, MJ, McKay, RD, Morrow, EM, Muotri, AR, Panchision, DM, Rubin, LL, Sawa, A, Soldner, F, Song, H, Studer, L, Temple, S, Vaccarino, FM, Wu, J, Vanderhaeghen, P, Gage, FH & Jaenisch, R 2015, 'Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders', Stem Cell Reports, vol. 5, no. 6, pp. 933-945. https://doi.org/10.1016/j.stemcr.2015.10.011
Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC et al. Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 8;5(6):933-945. https://doi.org/10.1016/j.stemcr.2015.10.011
Brennand, Kristen J. ; Marchetto, M. Carol ; Benvenisty, Nissim ; Brüstle, Oliver ; Ebert, Allison ; Izpisua Belmonte, Juan Carlos ; Kaykas, Ajamete ; Lancaster, Madeline A. ; Livesey, Frederick J. ; McConnell, Michael J. ; McKay, Ronald D. ; Morrow, Eric M. ; Muotri, Alysson R. ; Panchision, David M. ; Rubin, Lee L. ; Sawa, Akira ; Soldner, Frank ; Song, Hongjun ; Studer, Lorenz ; Temple, Sally ; Vaccarino, Flora M. ; Wu, Jun ; Vanderhaeghen, Pierre ; Gage, Fred H. ; Jaenisch, Rudolf. / Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders. In: Stem Cell Reports. 2015 ; Vol. 5, No. 6. pp. 933-945.
@article{d58f153fc46a4c66b4919a663996a805,
title = "Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders",
abstract = "As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.",
author = "Brennand, {Kristen J.} and Marchetto, {M. Carol} and Nissim Benvenisty and Oliver Br{\"u}stle and Allison Ebert and {Izpisua Belmonte}, {Juan Carlos} and Ajamete Kaykas and Lancaster, {Madeline A.} and Livesey, {Frederick J.} and McConnell, {Michael J.} and McKay, {Ronald D.} and Morrow, {Eric M.} and Muotri, {Alysson R.} and Panchision, {David M.} and Rubin, {Lee L.} and Akira Sawa and Frank Soldner and Hongjun Song and Lorenz Studer and Sally Temple and Vaccarino, {Flora M.} and Jun Wu and Pierre Vanderhaeghen and Gage, {Fred H.} and Rudolf Jaenisch",
year = "2015",
month = "12",
day = "8",
doi = "10.1016/j.stemcr.2015.10.011",
language = "English (US)",
volume = "5",
pages = "933--945",
journal = "Stem Cell Reports",
issn = "2213-6711",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders

AU - Brennand, Kristen J.

AU - Marchetto, M. Carol

AU - Benvenisty, Nissim

AU - Brüstle, Oliver

AU - Ebert, Allison

AU - Izpisua Belmonte, Juan Carlos

AU - Kaykas, Ajamete

AU - Lancaster, Madeline A.

AU - Livesey, Frederick J.

AU - McConnell, Michael J.

AU - McKay, Ronald D.

AU - Morrow, Eric M.

AU - Muotri, Alysson R.

AU - Panchision, David M.

AU - Rubin, Lee L.

AU - Sawa, Akira

AU - Soldner, Frank

AU - Song, Hongjun

AU - Studer, Lorenz

AU - Temple, Sally

AU - Vaccarino, Flora M.

AU - Wu, Jun

AU - Vanderhaeghen, Pierre

AU - Gage, Fred H.

AU - Jaenisch, Rudolf

PY - 2015/12/8

Y1 - 2015/12/8

N2 - As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

AB - As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

UR - http://www.scopus.com/inward/record.url?scp=84949526040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949526040&partnerID=8YFLogxK

U2 - 10.1016/j.stemcr.2015.10.011

DO - 10.1016/j.stemcr.2015.10.011

M3 - Article

C2 - 26610635

AN - SCOPUS:84949526040

VL - 5

SP - 933

EP - 945

JO - Stem Cell Reports

JF - Stem Cell Reports

SN - 2213-6711

IS - 6

ER -