Cranial irradiation and platelet monoamine oxidase in ALL

C. P. Minniti; M. Caruso; D. Di Bella; A. Russo; G. Schilirò

doi:10.1159/000206286

Cranial irradiation and platelet monoamine oxidase in ALL

C. P. Minniti, M. Caruso, D. Di Bella, A. Russo, G. Schilirò

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Abstract

Prophylactic cranial irradiation in acute lymphoblastic leukemia (ALL) has been held responsible for long-term neuropsychological sequelae. This study evaluates the activity of monoamine oxidase (MAO) in children with ALL in first complete remission both before and after cranial irradiation, given to prevent central nervous system involvement. There was a significant decrease (p<0.025) in platelet MAO activity shortly after cranial irradiation. MAO activity values were in the normal range in patients investigated 3 months or more after the radiation treatment was completed. The pathogenesis and clinical relevance of this decrease are discussed.

Original language	English (US)
Pages (from-to)	86-88
Number of pages	3
Journal	Acta Haematologica
Volume	73
Issue number	2
DOIs	https://doi.org/10.1159/000206286
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Hematology

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title = "Cranial irradiation and platelet monoamine oxidase in ALL",

abstract = "Prophylactic cranial irradiation in acute lymphoblastic leukemia (ALL) has been held responsible for long-term neuropsychological sequelae. This study evaluates the activity of monoamine oxidase (MAO) in children with ALL in first complete remission both before and after cranial irradiation, given to prevent central nervous system involvement. There was a significant decrease (p<0.025) in platelet MAO activity shortly after cranial irradiation. MAO activity values were in the normal range in patients investigated 3 months or more after the radiation treatment was completed. The pathogenesis and clinical relevance of this decrease are discussed.",

author = "Minniti, {C. P.} and M. Caruso and {Di Bella}, D. and A. Russo and G. Schilir{\`o}",

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AU - Minniti, C. P.

AU - Caruso, M.

AU - Di Bella, D.

AU - Russo, A.

AU - Schilirò, G.

PY - 1985

Y1 - 1985

N2 - Prophylactic cranial irradiation in acute lymphoblastic leukemia (ALL) has been held responsible for long-term neuropsychological sequelae. This study evaluates the activity of monoamine oxidase (MAO) in children with ALL in first complete remission both before and after cranial irradiation, given to prevent central nervous system involvement. There was a significant decrease (p<0.025) in platelet MAO activity shortly after cranial irradiation. MAO activity values were in the normal range in patients investigated 3 months or more after the radiation treatment was completed. The pathogenesis and clinical relevance of this decrease are discussed.

AB - Prophylactic cranial irradiation in acute lymphoblastic leukemia (ALL) has been held responsible for long-term neuropsychological sequelae. This study evaluates the activity of monoamine oxidase (MAO) in children with ALL in first complete remission both before and after cranial irradiation, given to prevent central nervous system involvement. There was a significant decrease (p<0.025) in platelet MAO activity shortly after cranial irradiation. MAO activity values were in the normal range in patients investigated 3 months or more after the radiation treatment was completed. The pathogenesis and clinical relevance of this decrease are discussed.

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Cranial irradiation and platelet monoamine oxidase in ALL

Abstract

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