Cranial irradiation and platelet monoamine oxidase in ALL

C. P. Minniti; M. Caruso; D. Di Bella; A. Russo; G. Schilirò

doi:10.1159/000206286

Cranial irradiation and platelet monoamine oxidase in ALL

C. P. Minniti, M. Caruso, D. Di Bella, A. Russo, G. Schilirò

Research output: Contribution to journal › Article › peer-review

Abstract

Prophylactic cranial irradiation in acute lymphoblastic leukemia (ALL) has been held responsible for long-term neuropsychological sequelae. This study evaluates the activity of monoamine oxidase (MAO) in children with ALL in first complete remission both before and after cranial irradiation, given to prevent central nervous system involvement. There was a significant decrease (p<0.025) in platelet MAO activity shortly after cranial irradiation. MAO activity values were in the normal range in patients investigated 3 months or more after the radiation treatment was completed. The pathogenesis and clinical relevance of this decrease are discussed.

Original language	English (US)
Pages (from-to)	86-88
Number of pages	3
Journal	Acta Haematologica
Volume	73
Issue number	2
DOIs	https://doi.org/10.1159/000206286
State	Published - Jan 1 1985
Externally published	Yes

ASJC Scopus subject areas

Hematology

Access to Document

10.1159/000206286

Cite this

@article{5a2fd87886164d28964c99f94dccc70c,

title = "Cranial irradiation and platelet monoamine oxidase in ALL",

abstract = "Prophylactic cranial irradiation in acute lymphoblastic leukemia (ALL) has been held responsible for long-term neuropsychological sequelae. This study evaluates the activity of monoamine oxidase (MAO) in children with ALL in first complete remission both before and after cranial irradiation, given to prevent central nervous system involvement. There was a significant decrease (p<0.025) in platelet MAO activity shortly after cranial irradiation. MAO activity values were in the normal range in patients investigated 3 months or more after the radiation treatment was completed. The pathogenesis and clinical relevance of this decrease are discussed.",

author = "Minniti, {C. P.} and M. Caruso and {Di Bella}, D. and A. Russo and G. Schilir{\`o}",

year = "1985",

month = jan,

day = "1",

doi = "10.1159/000206286",

language = "English (US)",

volume = "73",

pages = "86--88",

journal = "Acta Haematologica",

issn = "0001-5792",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - Cranial irradiation and platelet monoamine oxidase in ALL

AU - Minniti, C. P.

AU - Caruso, M.

AU - Di Bella, D.

AU - Russo, A.

AU - Schilirò, G.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Prophylactic cranial irradiation in acute lymphoblastic leukemia (ALL) has been held responsible for long-term neuropsychological sequelae. This study evaluates the activity of monoamine oxidase (MAO) in children with ALL in first complete remission both before and after cranial irradiation, given to prevent central nervous system involvement. There was a significant decrease (p<0.025) in platelet MAO activity shortly after cranial irradiation. MAO activity values were in the normal range in patients investigated 3 months or more after the radiation treatment was completed. The pathogenesis and clinical relevance of this decrease are discussed.

AB - Prophylactic cranial irradiation in acute lymphoblastic leukemia (ALL) has been held responsible for long-term neuropsychological sequelae. This study evaluates the activity of monoamine oxidase (MAO) in children with ALL in first complete remission both before and after cranial irradiation, given to prevent central nervous system involvement. There was a significant decrease (p<0.025) in platelet MAO activity shortly after cranial irradiation. MAO activity values were in the normal range in patients investigated 3 months or more after the radiation treatment was completed. The pathogenesis and clinical relevance of this decrease are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0021859673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021859673&partnerID=8YFLogxK

U2 - 10.1159/000206286

DO - 10.1159/000206286

M3 - Article

C2 - 3925692

AN - SCOPUS:0021859673

SN - 0001-5792

VL - 73

SP - 86

EP - 88

JO - Acta Haematologica

JF - Acta Haematologica

IS - 2

ER -

Cranial irradiation and platelet monoamine oxidase in ALL

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this