Could multiple low-affinity bonds mediate primary sperm-zona pellucida binding?

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The current model for primary sperm binding to the zona pellucida is that a cell-surface sperm protein binds with high affinity in an order-specific manner to one of the zona pellucida proteins, ZP3. However, the molecular details of primary sperm-zona pellucida binding remain elusive. A possible revised model is that multiple low-affinity bonds between spermatozoa and the zona pellucida may be sufficient for primary binding. The avidity of several low-affinity bonds can exceed that of a single high-affinity bond, which is sufficient to tether a motile spermatozoon. A mechanism involving multiple low-affinity bonds could account for some of the difficulties in elucidating primary sperm-zona pellucida interactions.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalReproduction
Volume124
Issue number1
StatePublished - 2002
Externally publishedYes

Fingerprint

Zona Pellucida
Spermatozoa
Membrane Proteins
Proteins

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Cell Biology
  • Endocrinology
  • Embryology

Cite this

Could multiple low-affinity bonds mediate primary sperm-zona pellucida binding? / Castle, Philip E.

In: Reproduction, Vol. 124, No. 1, 2002, p. 29-32.

Research output: Contribution to journalReview article

@article{97ff256582e543adb51a4e8779aa77a7,
title = "Could multiple low-affinity bonds mediate primary sperm-zona pellucida binding?",
abstract = "The current model for primary sperm binding to the zona pellucida is that a cell-surface sperm protein binds with high affinity in an order-specific manner to one of the zona pellucida proteins, ZP3. However, the molecular details of primary sperm-zona pellucida binding remain elusive. A possible revised model is that multiple low-affinity bonds between spermatozoa and the zona pellucida may be sufficient for primary binding. The avidity of several low-affinity bonds can exceed that of a single high-affinity bond, which is sufficient to tether a motile spermatozoon. A mechanism involving multiple low-affinity bonds could account for some of the difficulties in elucidating primary sperm-zona pellucida interactions.",
author = "Castle, {Philip E.}",
year = "2002",
language = "English (US)",
volume = "124",
pages = "29--32",
journal = "Reproduction",
issn = "1470-1626",
publisher = "BioScientifica Ltd.",
number = "1",

}

TY - JOUR

T1 - Could multiple low-affinity bonds mediate primary sperm-zona pellucida binding?

AU - Castle, Philip E.

PY - 2002

Y1 - 2002

N2 - The current model for primary sperm binding to the zona pellucida is that a cell-surface sperm protein binds with high affinity in an order-specific manner to one of the zona pellucida proteins, ZP3. However, the molecular details of primary sperm-zona pellucida binding remain elusive. A possible revised model is that multiple low-affinity bonds between spermatozoa and the zona pellucida may be sufficient for primary binding. The avidity of several low-affinity bonds can exceed that of a single high-affinity bond, which is sufficient to tether a motile spermatozoon. A mechanism involving multiple low-affinity bonds could account for some of the difficulties in elucidating primary sperm-zona pellucida interactions.

AB - The current model for primary sperm binding to the zona pellucida is that a cell-surface sperm protein binds with high affinity in an order-specific manner to one of the zona pellucida proteins, ZP3. However, the molecular details of primary sperm-zona pellucida binding remain elusive. A possible revised model is that multiple low-affinity bonds between spermatozoa and the zona pellucida may be sufficient for primary binding. The avidity of several low-affinity bonds can exceed that of a single high-affinity bond, which is sufficient to tether a motile spermatozoon. A mechanism involving multiple low-affinity bonds could account for some of the difficulties in elucidating primary sperm-zona pellucida interactions.

UR - http://www.scopus.com/inward/record.url?scp=0036061999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036061999&partnerID=8YFLogxK

M3 - Review article

C2 - 12090915

AN - SCOPUS:0036061999

VL - 124

SP - 29

EP - 32

JO - Reproduction

JF - Reproduction

SN - 1470-1626

IS - 1

ER -