Abstract
Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.
| Original language | English (US) |
|---|---|
| Article number | 165 |
| Journal | BMC Neurology |
| Volume | 13 |
| DOIs | |
| State | Published - Nov 6 2013 |
Keywords
- Cognitive ageing
- Cohort studies
- Data harmonisation
- Dementia
- International consortium
- Mild cognitive impairment
ASJC Scopus subject areas
- Clinical Neurology
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In: BMC Neurology, Vol. 13, 165, 06.11.2013.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - COSMIC (Cohort Studies of Memory in an International Consortium)
T2 - An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups
AU - Sachdev, Perminder S.
AU - Lipnicki, Darren M.
AU - Kochan, Nicole A.
AU - Crawford, John D.
AU - Rockwood, Kenneth
AU - Xiao, Shifu
AU - Li, Juan
AU - Li, Xia
AU - Brayne, Carol
AU - Matthews, Fiona E.
AU - Stephan, Blossom C.M.
AU - Lipton, Richard B.
AU - Katz, Mindy J.
AU - Ritchie, Karen
AU - Carrière, Isabelle
AU - Ancelin, Marie Laure
AU - Seshadri, Sudha
AU - Au, Rhoda
AU - Beiser, Alexa S.
AU - Lam, Linda C.W.
AU - Wong, Candy H.Y.
AU - Fung, Ada W.T.
AU - Kim, Ki W.
AU - Han, Ji W.
AU - Kim, Tae H.
AU - Petersen, Ronald C.
AU - Roberts, Rosebud O.
AU - Mielke, Michelle M.
AU - Ganguli, Mary
AU - Dodge, Hiroko H.
AU - Hughes, Tiffany
AU - Anstey, Kaarin J.
AU - Cherbuin, Nicolas
AU - Butterworth, Peter
AU - Ng, Tze P.
AU - Gao, Qi
AU - Reppermund, Simone
AU - Brodaty, Henry
AU - Meguro, Kenichi
AU - Schupf, Nicole
AU - Manly, Jennifer
AU - Stern, Yaakov
AU - Lobo, Antonio
AU - Lopez-Anton, Raúl
AU - Santabárbara, Javier
N1 - Funding Information: Funding from research grants (No. 03/121/17/214 and No. 08/1/21/19/567) from the Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore. Sydney Memory and Ageing Study (MAS): Perminder S Sachdev (study leader and consortium head), Darren M Lipnicki, Nicole A Kochan, John D Crawford, Simone Reppermund, Henry Brodaty (study leader). The authors acknowledge the contributions of members of the MAS Team: Allison Bowman, Kim Burns, Anthony Broe, Joula Dekker, Louise Dooley, Michele de Permentier, Sarah Fairjones, Janelle Fletcher, Therese French, Cathy Foster, Emma Nugent-Cleary-Fox, Chien Gooi, Evelyn Harvey, Rebecca Helyer, Sharpley Hsieh, Laura Hughes, Sarah Jacek, Mary Johnston, Donna McCade, Samantha Meeth, Eveline Milne, Angharad Moir, Ros O’Grady, Kia Pfaeffli, Carine Pose, Laura Reuser, Amanda Rose, Peter Schofield, Zeeshan Shahnawaz, Amanda Sharpley, Claire Thompson, Wiebke Queisser, and Sam Wong. Funding from a National Health & Medical Research Council of Australia Program Grant (ID 350833). Tajiri Project: Kenichi Meguro (study leader). The author acknowledges the contributions of Mari Kasai, Kei Nakamura, and Masahiro Nakatsuka. Washington Heights Inwood and Columbia Aging Project (WHICAP): Nicole Schupf (study leader), Jennifer Manly, Yaakov Stern. The authors acknowledge the contributions of Richard Mayeux, Principal Investigator of the WHICAP study, co-investigators Adam Brickman and Jose Luchsinger, and study team members Danurys Sanchez, Ming X. Tang and Howard Andrews. Funding from the National Institute of Health/National Institute on Aging: Grants # R01 AG037212, P01 AG07232. ZARADEMP Project (ZARAgoza DEMentia DEPression Project): Antonio Lobo (study leader), Raúl Lopez-Anton, Javier Santabárbara. The authors acknowledge the further study members Guillermo Marcos, Concepción De-la-Cámara, Pedro Saz, Tirso Ventura, Miguel Angel Quintanilla, and Elena Lobo, and the contributions of the ZARADEMP Workgroup who participated in the study. Funding from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain (grants 94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, and G03/128) and Pfizer Foundation, Madrid. Funding Information: leader). Funding from the National Health Research Development Program of Health Canada (6605-3954-MC[S]). Chinese Longitudinal Ageing Study (CLAS): Shifu Xiao (study leader), Juan Li, Xia Li. The authors extend their thanks to the main investigators from across the different regions of China: Tao Wang, Muni Tang, Wei Chen, Feng Bao, Huali Wang, Yuping Wang, Ying Liu, Yaping Wang, Yefeng Yuan, Xiaoyun Zuo, Zhongming Chen, Xulai Zhang, Lijuan Cui, Wenyuan Wu, Mingyuan Zhang. Funding from a China Ministry of Science and Technology grant (2009BAI77B03). Cognitive Function and Ageing Studies (CFAS): Carol Brayne (study leader), Fiona E Matthews, Blossom CM Stephan. Funding from major awards from the Medical Research Council and the Department of Health, UK. Einstein Aging Study (EAS): Richard B Lipton (study leader), Mindy J Katz (study leader). The authors acknowledge the contributions of Molly Zimmerman and Carol Derby. Funding from National Institute on Health/ National Institute on Aging grants: 5P01 AG003949, 1R03 AG045474. Etude Santé Psychologique Prévalence Risques et Traitement (ESPRIT): Karen Ritchie (study leader), Isabelle Carrière, Marie-Laure Ancelin (study leader). Funding from Novartis. Framingham Heart Study (FHS): Sudha Seshadri (study leader), Rhoda Au, Alexa S Beiser. The authors acknowledge the contributions of Philip A. Wolf and Galit A. Weinstein, and the dedication of the FHS participants. Funding from the National Heart, Lung and Blood Institute's Framingham Heart Study (Contract No. N01-HC-25195) and grants from the National Institute of Aging (AG08122, AG16495, AG033193), the National Institute of Neurological Disorders and Stroke (NS17950), and the National Heart, Lung and Blood Association (HL93029, U01HL 096917). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke, the National Heart Lung and Blood Institute, the National Institute of Aging or the National Institutes of Health. Hong Kong Memory and Ageing Prospective Study (HK-MAPS): Linda CW Lam (study leader), Candy HY Wong, Ada WT Fung. The authors acknowledge the contributions of Grace T.Y. Leung, Wai Chi Chan, Department of Health of Hong Kong SAR, the participants and the social centers for their assistance in the assessment, and thank Novartis and Astra Zeneca for their sponsorship of souvenirs for the participants in the baseline study. The baseline study is funded in part by the Mr. Lai Seung Hung & Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund, and by an educational fund from Eisai. Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD): Ki Woong Kim (study leader), Ji Won Han, Tae Hui Kim. Funding from a Korean Health Technology R&D Project grant from the Ministry for Health, Welfare, & Family Affairs, Republic of Korea (Grant No. A092077). Mayo Clinic Study of Aging (MCSA): Ronald C Petersen (study leader), Rosebud O Roberts, Michelle M Mielke. Funding from the National Institute on Aging: U01 AG006786, P50 AG016574, R01 AG034676. Monongahela Valley Independent Elders Survey (MoVIES): Mary Ganguli (study leader), Hiroko H Dodge, Tiffany Hughes. The authors acknowledge the contributions of 1681 study participants from the Monongahela Valley and of multiple MoVIES project personnel over the years. Funding from Grant # R01AG07562 from the National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services. Personality and Total Health (PATH) Through Life Project: Kaarin J Anstey (study leader), Nicolas Cherbuin, Peter Butterworth. The authors acknowledge the further study members Helen Christensen, Andrew MacKinnon, Simon Easteal, Project Managers Trish Jacomb, Karen Maxwell, participants and the NHMRC. Funding from National Health and Medical Research Council of Australia grants 973302, 179805, 157125 and 1002160. Singapore Longitudinal Ageing Studies (SLAS) I and II: Tze Pin Ng (study leader), Qi Gao. The authors gratefully thank the help and support of the following voluntary welfare organizations: Geylang East Home for the Aged, Presbysterian Community Services, Thye Hua Kwan Moral Society (Moral Neighbourhood Links), Yuhua Neighbourhood Link, Henderson Senior Citizens’ Home, NTUC Eldercare Co-op Ltd, Thong Kheng Seniors Activity Centre (Queenstown Centre) and Redhill Moral Seniors Activity Centre.
PY - 2013/11/6
Y1 - 2013/11/6
N2 - Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.
AB - Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.
KW - Cognitive ageing
KW - Cohort studies
KW - Data harmonisation
KW - Dementia
KW - International consortium
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=84887346944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887346944&partnerID=8YFLogxK
U2 - 10.1186/1471-2377-13-165
DO - 10.1186/1471-2377-13-165
M3 - Article
C2 - 24195705
AN - SCOPUS:84887346944
SN - 1471-2377
VL - 13
JO - BMC Neurology
JF - BMC Neurology
M1 - 165
ER -