Corticotropin-releasing hormone and pituitary-adrenal hormones in pregnancies complicated by chronic hypertension

Wendy B. Warren, Edith D. Gurewitsch Allen, Robin S. Goland

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVE: We hypothesized that maternal plasma corticotropin-releasing hormone levels are elevated in chronic hypertension and that elevations modulate maternal and fetal pituitary-adrenal function. STUDY DESIGN: Venous blood samples and 24-hour urine speciemsn were obtained in normal and hypertensive pregnancies at 21 to 40 weeks of gestatin. Corticotropin-releasing hormone, corticotropin, cortisol, dehydroepiandrosterone sulfate, and total estriol levels were measured by radioimmunoassay. Mean hormone levels were compared by unpaired t test or two-way analysis of variance. RESULTS: Plasma corticotropin-releasing hormone levels were elevated early in hypertensive pregnancies but did not increase after 36 weeks. Levels of pituitary and adrenal hormones were not different in normal and hypertensive women. However, maternal plasma estriol levels were lower in hypertensive pregnancies compared with normal pregnancies. CONCLUSIONS: Fetal 16-hydroxy dehydroeplandrosterone sulfate, the major precursors to placental estriol production, has been reported to be lower than normal in hypertensive pregnancies, possibly explaining the decreased plasma estriol levels reported here. Early stimulation of placental corticotropin-releasing hormone production or section may be related to accelerated maturation of placental endocrine function in pregnancies complicated by chronic hypertension.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume172
Issue number2 PART 1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Pituitary Hormones
Corticotropin-Releasing Hormone
Estriol
Hypertension
Pregnancy
Mothers
Placental Hormones
Dehydroepiandrosterone Sulfate
Adrenocorticotropic Hormone
Sulfates
Radioimmunoassay
Analysis of Variance
Urine
Hormones

Keywords

  • adrenal
  • chronic hypertension
  • corticotropin-releasing hormone
  • estriol
  • Placenta

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Corticotropin-releasing hormone and pituitary-adrenal hormones in pregnancies complicated by chronic hypertension. / Warren, Wendy B.; Gurewitsch Allen, Edith D.; Goland, Robin S.

In: American Journal of Obstetrics and Gynecology, Vol. 172, No. 2 PART 1, 01.01.1995, p. 661-666.

Research output: Contribution to journalArticle

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