Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus

Gerardo G. Piroli, Claudia A. Grillo, Leah R. Reznikov, Sheila Adams, Bruce S. McEwen, Maureen J. Charron, Lawrence P. Reagan

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Background: Exposure to stress levels of glucocorticoids produces physiological responses that are characteristic of type 2 diabetes, such as peripheral insulin resistance and impairment in insulin-stimulated trafficking of glucose transporter 4 (GLUT4) in muscle and fat. In the central nervous system, stress produces neuroanatomical and neurochemical changes in the hippocampus that are associated with cognitive impairments. Methods: In view of these observations, the current studies examined the effects of short-term (1 week) exposure of stress levels of glucocorticoids upon insulin receptor (IR) expression and signaling, including GLUT4 translocation, in the rat hippocampus. Results: One week of corticosterone (CORT) treatment produced insulin resistance in response to peripheral glucose challenge. In the hippocampus, IR expression was unchanged in CORT-treated rats as compared with vehicle-treated rats. However, insulin-stimulated phosphorylation of the IR, total Akt levels and total GLUT4 levels were reduced in CORT-treated rats when compared to controls. In addition, insulin-stimulated translocation of hippocampal GLUT4 to the plasma membrane was completely abolished in CORT-treated rats. Conclusions: These results demonstrate that in addition to eliciting peripheral insulin resistance, short-term CORT administration impairs insulin signaling in the rat hippocampus, effects that may contribute to the deleterious consequences of hypercortisolemic/hyperglycemic states observed in type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)71-80
Number of pages10
JournalNeuroendocrinology
Volume85
Issue number2
DOIs
StatePublished - May 2007

Fingerprint

Facilitative Glucose Transport Proteins
Corticosterone
Hippocampus
Insulin
Insulin Receptor
Insulin Resistance
Vascular Resistance
Type 2 Diabetes Mellitus
Glucocorticoids
Central Nervous System
Fats
Phosphorylation
Cell Membrane
Glucose
Muscles

Keywords

  • Akt levels
  • Diabetes
  • Glucocorticoid
  • Glucose
  • Hyperglycemia
  • Insulin resistance

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Piroli, G. G., Grillo, C. A., Reznikov, L. R., Adams, S., McEwen, B. S., Charron, M. J., & Reagan, L. P. (2007). Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus. Neuroendocrinology, 85(2), 71-80. https://doi.org/10.1159/000101694

Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus. / Piroli, Gerardo G.; Grillo, Claudia A.; Reznikov, Leah R.; Adams, Sheila; McEwen, Bruce S.; Charron, Maureen J.; Reagan, Lawrence P.

In: Neuroendocrinology, Vol. 85, No. 2, 05.2007, p. 71-80.

Research output: Contribution to journalArticle

Piroli, GG, Grillo, CA, Reznikov, LR, Adams, S, McEwen, BS, Charron, MJ & Reagan, LP 2007, 'Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus', Neuroendocrinology, vol. 85, no. 2, pp. 71-80. https://doi.org/10.1159/000101694
Piroli, Gerardo G. ; Grillo, Claudia A. ; Reznikov, Leah R. ; Adams, Sheila ; McEwen, Bruce S. ; Charron, Maureen J. ; Reagan, Lawrence P. / Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus. In: Neuroendocrinology. 2007 ; Vol. 85, No. 2. pp. 71-80.
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