Corticosteroid treatment for pulmonary lymphoid hyperplasia in children with the acquired immune deficiency syndrome.

Arye Rubinstein, L. J. Bernstein, M. Charytan, B. Z. Krieger, M. Ziprkowski

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Five children with positive serology for human immunodeficiency virus (HIV) infection by enzyme-linked immunosorbent assay and Western blot were followed for chronic pulmonary disease. Lung biopsies were performed in all patients, and confirmed the diagnosis of pulmonary lymphoid hyperplasia. All children demonstrated progressive hypoxia and increasing alveolar capillary oxygen gradients over at least 1 year of follow-up. All children were on periodic intravenous gamma globulin treatment for a B-cell defect prior to the initiation of corticosteroid therapy. Prednisone was initially given at a dose of 2 mg/kg daily and was subsequently tapered to an alternate day regimen. All children showed improvement in oxygenation. No deterioration in immune function was noted, and there was no increase in bacterial infection. This study indicates that corticosteroids can successfully reverse the severe hypoxia that may result from pulmonary lymphoid hyperplasia in pediatric AIDS patients.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalPediatric Pulmonology
Volume4
Issue number1
StatePublished - Jan 1988

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Hyperplasia
Adrenal Cortex Hormones
Acquired Immunodeficiency Syndrome
Lung
gamma-Globulins
Virus Diseases
Serology
Therapeutics
Prednisone
Bacterial Infections
Lung Diseases
B-Lymphocytes
Chronic Disease
Western Blotting
Enzyme-Linked Immunosorbent Assay
HIV
Pediatrics
Oxygen
Biopsy
Hypoxia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Corticosteroid treatment for pulmonary lymphoid hyperplasia in children with the acquired immune deficiency syndrome. / Rubinstein, Arye; Bernstein, L. J.; Charytan, M.; Krieger, B. Z.; Ziprkowski, M.

In: Pediatric Pulmonology, Vol. 4, No. 1, 01.1988, p. 13-17.

Research output: Contribution to journalArticle

Rubinstein, Arye ; Bernstein, L. J. ; Charytan, M. ; Krieger, B. Z. ; Ziprkowski, M. / Corticosteroid treatment for pulmonary lymphoid hyperplasia in children with the acquired immune deficiency syndrome. In: Pediatric Pulmonology. 1988 ; Vol. 4, No. 1. pp. 13-17.
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