Correlations in V1 are reduced by stimulation outside the receptive field

Adam C. Snyder, Michael J. Morais, Adam Kohn, Matthew A. Smith

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The trial-to-trial response variability of nearby cortical neurons is correlated. These correlations may strongly influence population coding performance. Numerous studies have shown that correlations can be dynamically modified by attention, adaptation, learning, and potent stimulus drive. However, the mechanisms that influence correlation strength remain poorly understood. Here we test whether correlations are influenced by presenting stimuli outside the classical receptive field (RF) of visual neurons, where they recruit a normalization signal termed surround suppression. We recorded simultaneously the activity of dozens of cells using microelectrode arrays implanted in the superficial layers of V1 in anesthetized, paralyzed macaque monkeys. We presented annular stimuli that encircled-but did not impinge upon-the RFs of the recorded cells. We found that these "extra-classical" stimuli reduced correlations in the absence of stimulation of the RF, closely resembling the decorrelating effects of stimulating the RFs directly. Our results suggest that normalization signals may be an important mechanism for modulating correlations.

Original languageEnglish (US)
Pages (from-to)11222-11227
Number of pages6
JournalJournal of Neuroscience
Volume34
Issue number34
DOIs
StatePublished - Aug 20 2014

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Neurons
Macaca
Microelectrodes
Visual Fields
Haplorhini
Learning
Population
Drive

Keywords

  • Electrophysiology
  • Extra-classical receptive field
  • Population coding
  • Spike count correlation
  • Surround suppression
  • V1

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Correlations in V1 are reduced by stimulation outside the receptive field. / Snyder, Adam C.; Morais, Michael J.; Kohn, Adam; Smith, Matthew A.

In: Journal of Neuroscience, Vol. 34, No. 34, 20.08.2014, p. 11222-11227.

Research output: Contribution to journalArticle

Snyder, Adam C. ; Morais, Michael J. ; Kohn, Adam ; Smith, Matthew A. / Correlations in V1 are reduced by stimulation outside the receptive field. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 34. pp. 11222-11227.
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