Correlations and dissociations between myosin isoenzymes and cardiac function

Richard N. Kitsis, J. Scheuer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Since the observation a decade ago that several isoforms of myosin exist with differing ATPase activities, attempts have been made to correlate cardiac contractile function with myosin isoform composition. In some species, various physical and hormonal interventions have been shown to effect parallel alterations in both cardiac function and myosin isoenzyme makeup. In other species and certain experimental situations, a dissociation between cardiac function and myosin isoforms has been noted. These findings support the hypothesis that myosin isoforms play a role in determining cardiac function, but that this regulation is shared with other control systems as well. In this paper we review some of the data demonstrating a correlation and other experiments showing a dissociation between contractile function and myosin isoenzymes.

Original languageEnglish (US)
Pages (from-to)327-337
Number of pages11
JournalJournal of Applied Cardiology
Volume3
Issue number5
StatePublished - 1988

Fingerprint

Cardiac Myosins
Myosins
Isoenzymes
Protein Isoforms
Adenosine Triphosphatases
Observation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Correlations and dissociations between myosin isoenzymes and cardiac function. / Kitsis, Richard N.; Scheuer, J.

In: Journal of Applied Cardiology, Vol. 3, No. 5, 1988, p. 327-337.

Research output: Contribution to journalArticle

@article{0ebd72cc096f448a808a37e122256948,
title = "Correlations and dissociations between myosin isoenzymes and cardiac function",
abstract = "Since the observation a decade ago that several isoforms of myosin exist with differing ATPase activities, attempts have been made to correlate cardiac contractile function with myosin isoform composition. In some species, various physical and hormonal interventions have been shown to effect parallel alterations in both cardiac function and myosin isoenzyme makeup. In other species and certain experimental situations, a dissociation between cardiac function and myosin isoforms has been noted. These findings support the hypothesis that myosin isoforms play a role in determining cardiac function, but that this regulation is shared with other control systems as well. In this paper we review some of the data demonstrating a correlation and other experiments showing a dissociation between contractile function and myosin isoenzymes.",
author = "Kitsis, {Richard N.} and J. Scheuer",
year = "1988",
language = "English (US)",
volume = "3",
pages = "327--337",
journal = "Journal of Applied Cardiology",
issn = "0883-2935",
number = "5",

}

TY - JOUR

T1 - Correlations and dissociations between myosin isoenzymes and cardiac function

AU - Kitsis, Richard N.

AU - Scheuer, J.

PY - 1988

Y1 - 1988

N2 - Since the observation a decade ago that several isoforms of myosin exist with differing ATPase activities, attempts have been made to correlate cardiac contractile function with myosin isoform composition. In some species, various physical and hormonal interventions have been shown to effect parallel alterations in both cardiac function and myosin isoenzyme makeup. In other species and certain experimental situations, a dissociation between cardiac function and myosin isoforms has been noted. These findings support the hypothesis that myosin isoforms play a role in determining cardiac function, but that this regulation is shared with other control systems as well. In this paper we review some of the data demonstrating a correlation and other experiments showing a dissociation between contractile function and myosin isoenzymes.

AB - Since the observation a decade ago that several isoforms of myosin exist with differing ATPase activities, attempts have been made to correlate cardiac contractile function with myosin isoform composition. In some species, various physical and hormonal interventions have been shown to effect parallel alterations in both cardiac function and myosin isoenzyme makeup. In other species and certain experimental situations, a dissociation between cardiac function and myosin isoforms has been noted. These findings support the hypothesis that myosin isoforms play a role in determining cardiac function, but that this regulation is shared with other control systems as well. In this paper we review some of the data demonstrating a correlation and other experiments showing a dissociation between contractile function and myosin isoenzymes.

UR - http://www.scopus.com/inward/record.url?scp=0023708583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023708583&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0023708583

VL - 3

SP - 327

EP - 337

JO - Journal of Applied Cardiology

JF - Journal of Applied Cardiology

SN - 0883-2935

IS - 5

ER -