TY - JOUR
T1 - Correlation of serum vaspin with cardiovascular risk factors in T2DM
AU - Kumari, Priya
AU - Bansal, S. K.
AU - Sharma, D. K.
AU - Yadav, Birendra Kumar
N1 - Publisher Copyright:
© 2020, Radiance Research Academy. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/3
Y1 - 2020/3
N2 - Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.
AB - Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.
KW - Risk factors
KW - T2DM
KW - Vaspin and Ox-LDL
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U2 - 10.31782/IJCRR.2020.12053
DO - 10.31782/IJCRR.2020.12053
M3 - Article
AN - SCOPUS:85090744738
VL - 12
SP - 13
EP - 18
JO - International Journal of Current Research and Review
JF - International Journal of Current Research and Review
SN - 2231-2196
IS - 5
ER -