Correlation of serum vaspin with cardiovascular risk factors in T2DM

Priya Kumari, S. K. Bansal, D. K. Sharma, Birendra Kumar Yadav

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalInternational Journal of Current Research and Review
Volume12
Issue number5
DOIs
StatePublished - Mar 2020
Externally publishedYes

Keywords

  • Risk factors
  • T2DM
  • Vaspin and Ox-LDL

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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