TY - JOUR
T1 - Correlation of serum vaspin with cardiovascular risk factors in T2DM
AU - Kumari, Priya
AU - Bansal, S. K.
AU - Sharma, D. K.
AU - Yadav, Birendra Kumar
N1 - Funding Information:
The author of the present manuscript would like to express his gratitude to his supervisor for providing a timely help and logistic facilities to carry out this work in the Department of Botany and Forestry, Vidyasagar University, Midnapore, West Bengal. The author is also thankful to the local communities whose support was impressive during the collection period of lichens.
Publisher Copyright:
© 2020, Radiance Research Academy. All rights reserved.
PY - 2020/3
Y1 - 2020/3
N2 - Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.
AB - Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.
KW - Risk factors
KW - T2DM
KW - Vaspin and Ox-LDL
UR - http://www.scopus.com/inward/record.url?scp=85090744738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090744738&partnerID=8YFLogxK
U2 - 10.31782/IJCRR.2020.12053
DO - 10.31782/IJCRR.2020.12053
M3 - Article
AN - SCOPUS:85090744738
VL - 12
SP - 13
EP - 18
JO - International Journal of Current Research and Review
JF - International Journal of Current Research and Review
SN - 2231-2196
IS - 5
ER -