Correlation of serum vaspin with cardiovascular risk factors in T2DM

Priya Kumari; S. K. Bansal; D. K. Sharma; Birendra Kumar Yadav

doi:10.31782/IJCRR.2020.12053

Correlation of serum vaspin with cardiovascular risk factors in T2DM

Priya Kumari, S. K. Bansal, D. K. Sharma, Birendra Kumar Yadav

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	International Journal of Current Research and Review
Volume	12
Issue number	5
DOIs	https://doi.org/10.31782/IJCRR.2020.12053
State	Published - Mar 2020
Externally published	Yes

Keywords

Risk factors
T2DM
Vaspin and Ox-LDL

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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title = "Correlation of serum vaspin with cardiovascular risk factors in T2DM",

abstract = "Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.",

keywords = "Risk factors, T2DM, Vaspin and Ox-LDL",

author = "Priya Kumari and Bansal, {S. K.} and Sharma, {D. K.} and Yadav, {Birendra Kumar}",

year = "2020",

month = mar,

doi = "10.31782/IJCRR.2020.12053",

language = "English (US)",

volume = "12",

pages = "13--18",

journal = "International Journal of Current Research and Review",

issn = "2231-2196",

publisher = "Radiance Research Academy",

number = "5",

}

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T1 - Correlation of serum vaspin with cardiovascular risk factors in T2DM

AU - Kumari, Priya

AU - Bansal, S. K.

AU - Sharma, D. K.

AU - Yadav, Birendra Kumar

PY - 2020/3

Y1 - 2020/3

N2 - Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.

AB - Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material & Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with agematched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides & Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P˂0.01) between Vaspin with BMI and LDL while negative correlation (P˂0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL & VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.

KW - Risk factors

KW - T2DM

KW - Vaspin and Ox-LDL

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Correlation of serum vaspin with cardiovascular risk factors in T2DM

Abstract

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