Correlation of IgM anti-hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV

S. Govindarajan, Sanjeev Gupta, B. Valinluck, A. G. Redeker

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

One hundred forty-four serum samples from 52 patients with chronic hepatitis D virus infection were analyzed for hepatitis D virus RNA by dot-blot hybridization using hepatitis D virus cDNA probe labeled with 32P. The results were correlated with the presence of serum IgM anti-hepatitis D virus and hepatitis D antigen in liver biopsy specimens when available. Although there was a trend of positive correlation between serum hepatitis D virus RNA and IgM anti-hepatitis D virus, no statistical significance could be found. In the serum samples with hepatitis D virus RNA, 32% were found to be negative for IgM anti-hepatitis D virus. Therefore, in chronic hepatitis D virus, absence of IgM anti-hepatitis D virus does not rule out active viral infection, as suggested by previous studies. There was a strong correlation between serum hepatitis D virus RNA and hepatic hepatitis D virus antigen. These data indicate that detection of hepatitis D virus RNA in serum samples is a reliable noninvasive marker of active viral infection.

Original languageEnglish (US)
Pages (from-to)34-35
Number of pages2
JournalHepatology
Volume10
Issue number1
StatePublished - 1989

Fingerprint

Chronic Hepatitis D
Hepatitis Delta Virus
Immunoglobulin M
Serum
Virus Diseases
Hepatitis delta Antigens
RHO(D) antibody
DNA-like RNA
Liver

ASJC Scopus subject areas

  • Hepatology

Cite this

Govindarajan, S., Gupta, S., Valinluck, B., & Redeker, A. G. (1989). Correlation of IgM anti-hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV. Hepatology, 10(1), 34-35.

Correlation of IgM anti-hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV. / Govindarajan, S.; Gupta, Sanjeev; Valinluck, B.; Redeker, A. G.

In: Hepatology, Vol. 10, No. 1, 1989, p. 34-35.

Research output: Contribution to journalArticle

Govindarajan, S, Gupta, S, Valinluck, B & Redeker, AG 1989, 'Correlation of IgM anti-hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV', Hepatology, vol. 10, no. 1, pp. 34-35.
Govindarajan, S. ; Gupta, Sanjeev ; Valinluck, B. ; Redeker, A. G. / Correlation of IgM anti-hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV. In: Hepatology. 1989 ; Vol. 10, No. 1. pp. 34-35.
@article{6afac41954234a6795334ef07c7ca759,
title = "Correlation of IgM anti-hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV",
abstract = "One hundred forty-four serum samples from 52 patients with chronic hepatitis D virus infection were analyzed for hepatitis D virus RNA by dot-blot hybridization using hepatitis D virus cDNA probe labeled with 32P. The results were correlated with the presence of serum IgM anti-hepatitis D virus and hepatitis D antigen in liver biopsy specimens when available. Although there was a trend of positive correlation between serum hepatitis D virus RNA and IgM anti-hepatitis D virus, no statistical significance could be found. In the serum samples with hepatitis D virus RNA, 32{\%} were found to be negative for IgM anti-hepatitis D virus. Therefore, in chronic hepatitis D virus, absence of IgM anti-hepatitis D virus does not rule out active viral infection, as suggested by previous studies. There was a strong correlation between serum hepatitis D virus RNA and hepatic hepatitis D virus antigen. These data indicate that detection of hepatitis D virus RNA in serum samples is a reliable noninvasive marker of active viral infection.",
author = "S. Govindarajan and Sanjeev Gupta and B. Valinluck and Redeker, {A. G.}",
year = "1989",
language = "English (US)",
volume = "10",
pages = "34--35",
journal = "Hepatology",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Correlation of IgM anti-hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV

AU - Govindarajan, S.

AU - Gupta, Sanjeev

AU - Valinluck, B.

AU - Redeker, A. G.

PY - 1989

Y1 - 1989

N2 - One hundred forty-four serum samples from 52 patients with chronic hepatitis D virus infection were analyzed for hepatitis D virus RNA by dot-blot hybridization using hepatitis D virus cDNA probe labeled with 32P. The results were correlated with the presence of serum IgM anti-hepatitis D virus and hepatitis D antigen in liver biopsy specimens when available. Although there was a trend of positive correlation between serum hepatitis D virus RNA and IgM anti-hepatitis D virus, no statistical significance could be found. In the serum samples with hepatitis D virus RNA, 32% were found to be negative for IgM anti-hepatitis D virus. Therefore, in chronic hepatitis D virus, absence of IgM anti-hepatitis D virus does not rule out active viral infection, as suggested by previous studies. There was a strong correlation between serum hepatitis D virus RNA and hepatic hepatitis D virus antigen. These data indicate that detection of hepatitis D virus RNA in serum samples is a reliable noninvasive marker of active viral infection.

AB - One hundred forty-four serum samples from 52 patients with chronic hepatitis D virus infection were analyzed for hepatitis D virus RNA by dot-blot hybridization using hepatitis D virus cDNA probe labeled with 32P. The results were correlated with the presence of serum IgM anti-hepatitis D virus and hepatitis D antigen in liver biopsy specimens when available. Although there was a trend of positive correlation between serum hepatitis D virus RNA and IgM anti-hepatitis D virus, no statistical significance could be found. In the serum samples with hepatitis D virus RNA, 32% were found to be negative for IgM anti-hepatitis D virus. Therefore, in chronic hepatitis D virus, absence of IgM anti-hepatitis D virus does not rule out active viral infection, as suggested by previous studies. There was a strong correlation between serum hepatitis D virus RNA and hepatic hepatitis D virus antigen. These data indicate that detection of hepatitis D virus RNA in serum samples is a reliable noninvasive marker of active viral infection.

UR - http://www.scopus.com/inward/record.url?scp=0024411816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024411816&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 34

EP - 35

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 1

ER -