TY - JOUR
T1 - Correlation of IgM anti‐hepatitis D virus (HDV) to HDV RNA in sera of chronic HDV
AU - Govindarajan, Sugantha
AU - Gupta, Sanjeev
AU - Valinluck, Boontar
AU - Redeker, Allan G.
PY - 1989/7
Y1 - 1989/7
N2 - One hundred forty‐four serum samples from 52 patients with chronic hepatitis D virus infection were analyzed for hepatitis D virus RNA by dot‐blot hybridization using hepatitis D virus cDNA probe labeled with 32p. The results were correlated with the presence of serum IgM anti‐hepatitis D virus and hepatitis D antigen in liver biopsy specimens when available. Although there was a trend of positive correlation between serum hepatitis D virus RNA and IgM anti‐hepatitis D virus, no statistical significance could be found. In the serum samples with hepatitis D virus RNA, 32% were found to be negative for IgM anti‐hepatitis D virus. Therefore, in chronic hepatitis D virus, absence of IgM anti‐hepatitis D virus does not rule out active viral infection, as suggested by previous studies. There was a strong correlation between serum hepatitis D virus RNA and hepatic hepatitis D virus antigen. These data indicate that detection of hepatitis D virus RNA in serum samples is a reliable noninvasive marker of active viral infection.
AB - One hundred forty‐four serum samples from 52 patients with chronic hepatitis D virus infection were analyzed for hepatitis D virus RNA by dot‐blot hybridization using hepatitis D virus cDNA probe labeled with 32p. The results were correlated with the presence of serum IgM anti‐hepatitis D virus and hepatitis D antigen in liver biopsy specimens when available. Although there was a trend of positive correlation between serum hepatitis D virus RNA and IgM anti‐hepatitis D virus, no statistical significance could be found. In the serum samples with hepatitis D virus RNA, 32% were found to be negative for IgM anti‐hepatitis D virus. Therefore, in chronic hepatitis D virus, absence of IgM anti‐hepatitis D virus does not rule out active viral infection, as suggested by previous studies. There was a strong correlation between serum hepatitis D virus RNA and hepatic hepatitis D virus antigen. These data indicate that detection of hepatitis D virus RNA in serum samples is a reliable noninvasive marker of active viral infection.
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U2 - 10.1002/hep.1840100108
DO - 10.1002/hep.1840100108
M3 - Article
C2 - 2737601
AN - SCOPUS:0024411816
SN - 0270-9139
VL - 10
SP - 34
EP - 35
JO - Hepatology
JF - Hepatology
IS - 1
ER -
