Correlation between preoperative endoscopic ultrasound and surgical pathology staging of gastric adenocarcinoma: A single institution retrospective review

Oscar K. Serrano, Kevin Huang, Nicole Ng, Julie Yang, Patricia Friedmann, Steven K. Libutti, Timothy J. Kennedy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Recent evidence validates the effectiveness of neoadjuvant chemotherapy in the treatment of gastric adenocarcinoma. Endoscopic ultrasonographic (EUS) staging has been proposed as a useful adjunct in this setting. Methods We performed a retrospective review of patients treated at our institution for gastric adenocarcinoma between July 2005 and January 2014. We identified patients referred for EUS before surgery as part of a prospective treatment plan. Histopathologic staging was compared to EUS staging, with a focus on T- and N-stage. Agreement between the two modalities was examined using kappa-statistics. Results We identified 614 patients with biopsy-proven gastric adenocarcinoma; 145 underwent curative-intent surgery. Surgical pathology and EUS results were available from 69 patients. The accuracy of EUS for the evaluation of T- and N-stage was 44.9% and 56.5%, respectively. EUS demonstrated greater concordance with histopathology at evaluating T-stage (κ = 0.3469) than N-stage (κ = 0.1316). EUS underestimated T- and N-stage in 40.8% and 30.4% of patients, respectively. Conclusion EUS seems to correlate poorly with pathology in the preoperative staging of gastric adenocarcinoma. In the majority of inaccurate cases, EUS underestimates T-stage and N-stage, limiting its utility in the neoadjuvant setting.

Original languageEnglish (US)
Pages (from-to)42-45
Number of pages4
JournalJournal of Surgical Oncology
Volume113
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Surgical Pathology
Stomach
Adenocarcinoma
Pathology
Biopsy
Drug Therapy
Therapeutics

Keywords

  • adenocarcinoma
  • endoscopic ultrasound
  • gastric cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Correlation between preoperative endoscopic ultrasound and surgical pathology staging of gastric adenocarcinoma : A single institution retrospective review. / Serrano, Oscar K.; Huang, Kevin; Ng, Nicole; Yang, Julie; Friedmann, Patricia; Libutti, Steven K.; Kennedy, Timothy J.

In: Journal of Surgical Oncology, Vol. 113, No. 1, 01.01.2016, p. 42-45.

Research output: Contribution to journalArticle

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abstract = "Background Recent evidence validates the effectiveness of neoadjuvant chemotherapy in the treatment of gastric adenocarcinoma. Endoscopic ultrasonographic (EUS) staging has been proposed as a useful adjunct in this setting. Methods We performed a retrospective review of patients treated at our institution for gastric adenocarcinoma between July 2005 and January 2014. We identified patients referred for EUS before surgery as part of a prospective treatment plan. Histopathologic staging was compared to EUS staging, with a focus on T- and N-stage. Agreement between the two modalities was examined using kappa-statistics. Results We identified 614 patients with biopsy-proven gastric adenocarcinoma; 145 underwent curative-intent surgery. Surgical pathology and EUS results were available from 69 patients. The accuracy of EUS for the evaluation of T- and N-stage was 44.9{\%} and 56.5{\%}, respectively. EUS demonstrated greater concordance with histopathology at evaluating T-stage (κ = 0.3469) than N-stage (κ = 0.1316). EUS underestimated T- and N-stage in 40.8{\%} and 30.4{\%} of patients, respectively. Conclusion EUS seems to correlate poorly with pathology in the preoperative staging of gastric adenocarcinoma. In the majority of inaccurate cases, EUS underestimates T-stage and N-stage, limiting its utility in the neoadjuvant setting.",
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