TY - JOUR
T1 - Correlation between age-related changes in open field behavior and plaque forming cell response in da female rats
AU - Todorović, Čedomir
AU - Dimitrijević, Mirjana
AU - Stanojević, Stanislava
AU - Kovacevic-Jovanovic, Vesna
AU - Miletić, Tatjana
AU - Laban, Olgica
AU - Radulović, Jelena
N1 - Funding Information:
Received 27 January 2003. The technical assistance of Mrs. Zuzana Tomaš is gratefully acknowledged. This work was supported by the Ministry of Science, Technology and Development, Republic of Serbia, Belgrade, Yugoslavia (Grant 1239). Address correspondence to Mirjana Dimitrijevic, Immunology Research Center “Branislav Janković,” Institute of Immunology and Virology “Torlak,” Vojvode Stepe 458, 11152 Belgrade, Yugoslavia. E-mail: ilijadim@eunet.yu
PY - 2003/9/1
Y1 - 2003/9/1
N2 - We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.
AB - We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.
KW - Analgesia
KW - Forced-swim test
KW - Macrophages
KW - Open field
KW - Plaque forming cell response
KW - Rat
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U2 - 10.1080/00207450390212492
DO - 10.1080/00207450390212492
M3 - Article
C2 - 12959743
AN - SCOPUS:0141996941
SN - 0020-7454
VL - 113
SP - 1259
EP - 1273
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 9
ER -