Coronary artery dilation in sickle cell disease

George T. Nicholson, Daphne T. Hsu, Steven D. Colan, Deepa G. Manwani, William B. Burton, Darlene Fountain, Leo Lopez

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To evaluate the prevalence of coronary artery dilation in children with sickle cell disease (SCD). Study design: This is a retrospective analysis performed in patients, between 10 and 19 years old, with SCD who underwent a routine transthoracic echocardiographic evaluation over a 20-month period. The left main, left anterior descending, and proximal right coronary artery diameters, as well as clinical and laboratory variables and other echocardiographic results were collected. Echocardiographic measurements were converted to z scores by using information from a large control population of normal children. Coronary artery ectasia (CAE) was defined as a coronary artery diameter z score ≥2. The patients with CAE were compared with those without CAE by using univariate and multivariate analyses. Results: Seventeen of 96 patients with SCD (17.7%) had CAE. There were no differences in sex, age, height, weight, body surface area, or genotype between those with and those without CAE. Patients with CAE had larger left ventricular end-diastolic dimension, shortening fraction, septal thickness, posterior wall thickness, mass, mass-to-volume ratio, and white blood cell count. Multivariate analysis revealed that the mass-to-volume ratio and elevated white blood cell count were associated with CAE. Conclusion: CAE is common in SCD and is associated with left ventricular hypertrophy and inflammation.

Original languageEnglish (US)
JournalJournal of Pediatrics
Volume159
Issue number5
DOIs
StatePublished - Nov 2011

Fingerprint

Sickle Cell Anemia
Pathologic Dilatations
Dilatation
Coronary Vessels
Leukocyte Count
Multivariate Analysis
Body Surface Area
Left Ventricular Hypertrophy
Sex Characteristics
Genotype
Inflammation
Weights and Measures

Keywords

  • 2-dimensional
  • 2D
  • Body surface area
  • BSA
  • CAE
  • Coronary artery ectasia
  • EDD
  • EDV
  • EF
  • Ejection fraction
  • ESD
  • Hct
  • Hematocrit
  • Hemoglobin
  • Hgb
  • Lactate dehydrogenase
  • LAD
  • LDH
  • Left main coronary artery
  • Left ventricular
  • Left ventricular end-diastolic dimension
  • Left ventricular end-diastolic volume
  • Left ventricular end-systolic dimension
  • Left ventricular posterior wall thickness
  • LMCA
  • LV
  • Proximal left anterior descending coronary artery
  • Proximal right coronary artery
  • PWT
  • RCA
  • SCD
  • Septal thickness
  • SF
  • Shortening fraction
  • Sickle cell disease
  • ST
  • TCACA
  • Total proximal coronary artery cross-sectional area
  • WBC
  • White blood cell count

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Coronary artery dilation in sickle cell disease. / Nicholson, George T.; Hsu, Daphne T.; Colan, Steven D.; Manwani, Deepa G.; Burton, William B.; Fountain, Darlene; Lopez, Leo.

In: Journal of Pediatrics, Vol. 159, No. 5, 11.2011.

Research output: Contribution to journalArticle

Nicholson, George T. ; Hsu, Daphne T. ; Colan, Steven D. ; Manwani, Deepa G. ; Burton, William B. ; Fountain, Darlene ; Lopez, Leo. / Coronary artery dilation in sickle cell disease. In: Journal of Pediatrics. 2011 ; Vol. 159, No. 5.
@article{7414401d02584a19adbd808eef28f8ab,
title = "Coronary artery dilation in sickle cell disease",
abstract = "Objective: To evaluate the prevalence of coronary artery dilation in children with sickle cell disease (SCD). Study design: This is a retrospective analysis performed in patients, between 10 and 19 years old, with SCD who underwent a routine transthoracic echocardiographic evaluation over a 20-month period. The left main, left anterior descending, and proximal right coronary artery diameters, as well as clinical and laboratory variables and other echocardiographic results were collected. Echocardiographic measurements were converted to z scores by using information from a large control population of normal children. Coronary artery ectasia (CAE) was defined as a coronary artery diameter z score ≥2. The patients with CAE were compared with those without CAE by using univariate and multivariate analyses. Results: Seventeen of 96 patients with SCD (17.7{\%}) had CAE. There were no differences in sex, age, height, weight, body surface area, or genotype between those with and those without CAE. Patients with CAE had larger left ventricular end-diastolic dimension, shortening fraction, septal thickness, posterior wall thickness, mass, mass-to-volume ratio, and white blood cell count. Multivariate analysis revealed that the mass-to-volume ratio and elevated white blood cell count were associated with CAE. Conclusion: CAE is common in SCD and is associated with left ventricular hypertrophy and inflammation.",
keywords = "2-dimensional, 2D, Body surface area, BSA, CAE, Coronary artery ectasia, EDD, EDV, EF, Ejection fraction, ESD, Hct, Hematocrit, Hemoglobin, Hgb, Lactate dehydrogenase, LAD, LDH, Left main coronary artery, Left ventricular, Left ventricular end-diastolic dimension, Left ventricular end-diastolic volume, Left ventricular end-systolic dimension, Left ventricular posterior wall thickness, LMCA, LV, Proximal left anterior descending coronary artery, Proximal right coronary artery, PWT, RCA, SCD, Septal thickness, SF, Shortening fraction, Sickle cell disease, ST, TCACA, Total proximal coronary artery cross-sectional area, WBC, White blood cell count",
author = "Nicholson, {George T.} and Hsu, {Daphne T.} and Colan, {Steven D.} and Manwani, {Deepa G.} and Burton, {William B.} and Darlene Fountain and Leo Lopez",
year = "2011",
month = "11",
doi = "10.1016/j.jpeds.2011.05.013",
language = "English (US)",
volume = "159",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Coronary artery dilation in sickle cell disease

AU - Nicholson, George T.

AU - Hsu, Daphne T.

AU - Colan, Steven D.

AU - Manwani, Deepa G.

AU - Burton, William B.

AU - Fountain, Darlene

AU - Lopez, Leo

PY - 2011/11

Y1 - 2011/11

N2 - Objective: To evaluate the prevalence of coronary artery dilation in children with sickle cell disease (SCD). Study design: This is a retrospective analysis performed in patients, between 10 and 19 years old, with SCD who underwent a routine transthoracic echocardiographic evaluation over a 20-month period. The left main, left anterior descending, and proximal right coronary artery diameters, as well as clinical and laboratory variables and other echocardiographic results were collected. Echocardiographic measurements were converted to z scores by using information from a large control population of normal children. Coronary artery ectasia (CAE) was defined as a coronary artery diameter z score ≥2. The patients with CAE were compared with those without CAE by using univariate and multivariate analyses. Results: Seventeen of 96 patients with SCD (17.7%) had CAE. There were no differences in sex, age, height, weight, body surface area, or genotype between those with and those without CAE. Patients with CAE had larger left ventricular end-diastolic dimension, shortening fraction, septal thickness, posterior wall thickness, mass, mass-to-volume ratio, and white blood cell count. Multivariate analysis revealed that the mass-to-volume ratio and elevated white blood cell count were associated with CAE. Conclusion: CAE is common in SCD and is associated with left ventricular hypertrophy and inflammation.

AB - Objective: To evaluate the prevalence of coronary artery dilation in children with sickle cell disease (SCD). Study design: This is a retrospective analysis performed in patients, between 10 and 19 years old, with SCD who underwent a routine transthoracic echocardiographic evaluation over a 20-month period. The left main, left anterior descending, and proximal right coronary artery diameters, as well as clinical and laboratory variables and other echocardiographic results were collected. Echocardiographic measurements were converted to z scores by using information from a large control population of normal children. Coronary artery ectasia (CAE) was defined as a coronary artery diameter z score ≥2. The patients with CAE were compared with those without CAE by using univariate and multivariate analyses. Results: Seventeen of 96 patients with SCD (17.7%) had CAE. There were no differences in sex, age, height, weight, body surface area, or genotype between those with and those without CAE. Patients with CAE had larger left ventricular end-diastolic dimension, shortening fraction, septal thickness, posterior wall thickness, mass, mass-to-volume ratio, and white blood cell count. Multivariate analysis revealed that the mass-to-volume ratio and elevated white blood cell count were associated with CAE. Conclusion: CAE is common in SCD and is associated with left ventricular hypertrophy and inflammation.

KW - 2-dimensional

KW - 2D

KW - Body surface area

KW - BSA

KW - CAE

KW - Coronary artery ectasia

KW - EDD

KW - EDV

KW - EF

KW - Ejection fraction

KW - ESD

KW - Hct

KW - Hematocrit

KW - Hemoglobin

KW - Hgb

KW - Lactate dehydrogenase

KW - LAD

KW - LDH

KW - Left main coronary artery

KW - Left ventricular

KW - Left ventricular end-diastolic dimension

KW - Left ventricular end-diastolic volume

KW - Left ventricular end-systolic dimension

KW - Left ventricular posterior wall thickness

KW - LMCA

KW - LV

KW - Proximal left anterior descending coronary artery

KW - Proximal right coronary artery

KW - PWT

KW - RCA

KW - SCD

KW - Septal thickness

KW - SF

KW - Shortening fraction

KW - Sickle cell disease

KW - ST

KW - TCACA

KW - Total proximal coronary artery cross-sectional area

KW - WBC

KW - White blood cell count

UR - http://www.scopus.com/inward/record.url?scp=80054716834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054716834&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2011.05.013

DO - 10.1016/j.jpeds.2011.05.013

M3 - Article

VL - 159

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 5

ER -