Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis

Catherine Vilchèze, Yossef Av-Gay, S. Whitney Barnes, Michelle H. Larsen, John R. Walker, Richard J. Glynne, William R. Jacobs

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A search to identify new mechanisms of isoniazid resistance in Mycobacterium bovis led to the isolation of mutants defective in mycothiol biosynthesis due to mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants showed low-level resistance to isoniazid but were highly resistant to ethionamide. This study further illustrates that mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species.

Original languageEnglish (US)
Pages (from-to)4422-4423
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number9
DOIs
StatePublished - Sep 1 2011

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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