Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis

Catherine Vilchèze, Yossef Av-Gay, S. Whitney Barnes, Michelle H. Larsen, John R. Walker, Richard J. Glynne, William R. Jacobs

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A search to identify new mechanisms of isoniazid resistance in Mycobacterium bovis led to the isolation of mutants defective in mycothiol biosynthesis due to mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants showed low-level resistance to isoniazid but were highly resistant to ethionamide. This study further illustrates that mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species.

Original languageEnglish (US)
Pages (from-to)4422-4423
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number9
DOIs
StatePublished - Sep 2011

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Ethionamide
Isoniazid
Mycobacterium bovis
Genes
Glycosyltransferases
Mutation
Ligases
Cysteine
mycothiol

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis. / Vilchèze, Catherine; Av-Gay, Yossef; Barnes, S. Whitney; Larsen, Michelle H.; Walker, John R.; Glynne, Richard J.; Jacobs, William R.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 9, 09.2011, p. 4422-4423.

Research output: Contribution to journalArticle

Vilchèze, Catherine ; Av-Gay, Yossef ; Barnes, S. Whitney ; Larsen, Michelle H. ; Walker, John R. ; Glynne, Richard J. ; Jacobs, William R. / Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis. In: Antimicrobial Agents and Chemotherapy. 2011 ; Vol. 55, No. 9. pp. 4422-4423.
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